Lina Lukitasari and Lilik Herawati and Erwin Astha Triyono and Hendy Muagiri Margono and Soetjipto (2013) Hepatitis B Infection And Genotype Hepatitis B Virus Among Drug Abused In An Indonesian Teaching Hospital. International Journal of Academic Research, 5 (1). pp. 134-138. ISSN 2348-7666

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Abstract

South East Asia has high level endemicity of hepatitis B infection in the world. The hepatitis B virus (HBV) is transmitted by parenteral exposure from infected blood or body fluid. Drug abused group is one of the highest risk expose group of HVB infection. According to Indonesian National Narcotics Board, the drug abused case always rise every year. The aim of this study was to determine the hepatitis B infection among drug abused used Polymerase Chain Reaction (PCR) method, then sequence to determine the HBV genotype. First, hepatitis B infection determined by ELISA method in 101 sera from drug abused. Sera which had positive HBsAg will investigate later to determine the HBV DNA based on surface gen. Sera which had positive DNA HBV will be sequenced and analyzed using computer program version 9. In the result, Seven (6,93%) sera were detected had positive HBsAg from 101 sera and four (57,14%) sera were detected had HBV DNAs from 7 sera. Genotype B were detected in all positive HBV DNAs (100%). Conclusion, We had identified HBV DNA in HBsAg positive sera and others are not known whether it was hepatitis B infection or not. Thus, it is likely that genotype B of HBV is predominant in Indonesia. It needs further investigation to explore hepatitis B prevalence by molecular detection and genotype distribution with greater participant in HBsAg positive and negative.

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