Aris Setyawan (2019) Perbedaan Efektivitas Freeze-Dried Bovine Bone Xenograft Dengan Kombinasi Demineralized Freeze-Dried Bovine Bone Xenograft Dan Bovine Hidroxyapatite Terhadap Ekspresi Runx-2, Kolagen Tipe I Dan Jumlah Osteoblas Pada Defek Tulang Mandibula Kelinci (Penelitian Eksperimental Laboratorik In Vivo). Thesis thesis, UNIVERSITAS AIRLANGGA.

	Text 1. HALAMAN JUDUL .pdf Download (198kB)
	Text 2. ABSTRACT.pdf Download (60kB)
	Text 3. DAFTAR ISI.pdf Download (77kB)
	Text 4. BAB 1PENDAHULUAN.pdf Download (85kB)
	Text 5. BAB 2TINJAUAN PUSTAKA.pdf Restricted to Registered users only until 10 August 2023. Download (513kB) | Request a copy
	Text 6. BAB 3KERANGKA KONSEP DAN HIPOTESIS PENELITIAN.pdf Restricted to Registered users only until 10 August 2023. Download (90kB) | Request a copy
	Text 7. BAB 4METODE PENELITIAN.pdf Restricted to Registered users only until 10 August 2023. Download (184kB) | Request a copy
	Text 8. BAB 5HASIL PENELITIAN DAN ANALISIS DATA.pdf Restricted to Registered users only until 10 August 2023. Download (419kB) | Request a copy
	Text 9. BAB 6PEMBAHASAN.pdf Restricted to Registered users only until 10 August 2023. Download (85kB) | Request a copy
	Text 10. BAB 7KESIMPULAN DAN SARAN.pdf Restricted to Registered users only until 10 August 2023. Download (59kB) | Request a copy
	Text 11. DAFTAR PUSTAKA.pdf Download (79kB)
	Text 12. LAMPIRAN .pdf Restricted to Registered users only until 10 August 2023. Download (282kB) | Request a copy

Abstract

Background: Jaw resection and congenital abnormalities can cause defects in jaw bone. The surgical procedure for bone reconstruction currently performed is bone regeneration graft. Unfortunately, this procedure still has many disadvantages. Thus, tissue engineering approach is necessary to be conducted. The main component used in this tissue engineering is scaffolds. Scaffolds used in bone regeneration such as Freeze Dried Bovine Bone Xenograft (FDBBX), Demineralized Freeze Dried Bone Xenograft (DFDBBX) and bovine hydroxyapatite (BHA) are expected to have appropriate characteristics with bone. Objective: The aim of this study is observed the difference in bone healing processes between FDBX and the combination of DFDBBX and BHA. Materials and Methods: Bicortical bone defects were created in the angle of mandible 45 New Zealand White Rabbits. The groups were divided into 3 groups which the first group was treated with FDBBX, second group was treated with FDBBX and the control group was left perforated. All group were evaluated after second, fourth, and eighth weeks to count the number of osteoblast, Collagen-1 (Coll-1) and RUNX2 expression. Results: The FDBBX and DFDBBX-BHA was significantly higher compared to control (p<0.05) in the number of osteoblast, Collagen-1 (Coll-1) and RUNX2 expression . The number of osteoblast, Collagen- 1 (Coll-1) and RUNX2 expression in FDBBX compared to DFDBBX-BHA was not significant (p>0.05). Conclusion: FDBBX and DFDBBX-BHA has the high osteoblast cell proliferation, Collagen-1 (Coll-1) and RUNX2 expression, meaning have a good potential as future source of bone graft. FDBBX and DFDBBX-BHA has the same potential.

Actions (login required)

View Item