Jefry Wahyudi Safril (2019) Perbandingan Ekspresi Receptor Activator Of Nuclear Factor- Κβ Ligand Dan Osteoprotegerin Pasca Penanaman Kombinasi Demineralized Freeze Dried Bovine Bone Xenograft - Bovine Hydroxyapatite Dengan Freeze Dried Bovine Bone Xenograft Penelitian Eksperimental Laboratorik In Vivo Pada Defek Mandibula Kelinci. Thesis thesis, UNIVERSITAS AIRLANGGA.
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Abstract
Method: Ten millimeter round defect was made in the mandible angle of New Zealand White Rabbit and divided in three groups. The control group, FDBBX group, and DFDBBX and BHA mixture group. The observation time were: 2 weeks, 4 weeks and 8 weeks. The amount of osteoclast cells was observed using Hematoxylin Eosin (HE), and expression of RANKL and OPG were observed using Immunohistochemistry (IHC). Results:The amount of osteoclast cells in group of DFDBBX and BHA mixture was found lower with significant difference (p = 0.009) in 8 weeks observation compared to FDBBX group. The expression of RANKL in those groups in mixture was found lower with significant difference (p = 0.001), but not significant difference compared to FDBBX group. Comparing to control group, group of mixture of DFDBBX and BHA found that the OPG showed higher value (p = 0.005), but no significant difference compared with in FDBBX groups. Conclusion: FDBBX and mixture of DFDBBX and BHA showed a difference level in the amount of osteoclast means that graft material in a mixture of DFDBBX and BHA resorbed more slowly comparing to FDBBX. The slower of bone graft degradation as presented in DFDBBX and BHA combination can be related to its capacity in host bone stimulation
| Item Type: | Thesis (Thesis) | ||||||
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| Additional Information: | KKA KK Tkkli 08/20 Saf P | ||||||
| Uncontrolled Keywords: | Bovine Xenograft, RANK, RANKL, OPG | ||||||
| Subjects: | R Medicine > RA Public aspects of medicine > RA1-1270 Public aspects of medicine > RA1-418.5 Medicine and the state | ||||||
| Divisions: | 09. Sekolah Pasca Sarjana > Ilmu Kedokteran | ||||||
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| Depositing User: | Unnamed user with email indah.fatma@staf.unair.ac.id | ||||||
| Date Deposited: | 10 Aug 2020 15:09 | ||||||
| Last Modified: | 10 Aug 2020 15:09 | ||||||
| URI: | http://repository.unair.ac.id/id/eprint/96910 | ||||||
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