Muhammad Hamdan and Moh. Hasan Machfoed and Paulus Sugianto and Achmad Firdaus Sani and Mohammad Saiful Ardhi and Fadil (2020) The Association of Lipoprotein-a Levels, Neutrophil Lymphocyte Ratio and Hypertension with the Clinical Severity Scale Measured by NIHSS Scale in Patients with Acute Thrombotic Stroke. Medico-legal Update, 20 (2). pp. 658-663. ISSN 0971720X

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Abstract

Background: The correlation between levels of Lipoprotein-a, Neutrophil Lymphocyte Ratio and hypertension with clinical severity scale remains a controversial issue. Objective: To determine the correlation of levels of Lipoprotein-a, Neutrophil Lymphocyte Ratio and hypertension with the severity scale measured by NIHSS scale in patients with acute thrombotic stroke. Method: Lipoprotein-a levels, Neutrophil Lymphocyte ratio, blood pressure in patients with acute thrombotic stroke were measured and clinical severity scale was assessed by NIHSS scale. The levels of lipoprotein-a were grouped into normal and high levels of lipoprotein-a, Lymphocyte Neutrophil Ratios were grouped into low and high and hypertension were grouped into stage 1 and 2. The data was analyzed using logistic regression. Results: There were 40 patients consisting of 29 (72.50%) male patients and 11 (27.50%) female patients. The demographic data included gender, age, LDL level, random blood sugar level, diabetes mellitus status and smoking status which were all homogeneous in both groups of lipoprotein-a, Neutrophil Lymphocyte ratio and hypertension stage. In the logistic regression analysis, the lipoprotein-a and neutrophil lymphocyte ratio were correlated with clinical severity scale (p = 0.018, RO 0.122 (CI 95% 0.022-0.696) vs p = 0.041, RO 0.068 (95% CI 0.005-0.895) while hypertension stage was not correlated with clinical severity scale (p = 0.97, RO 1.02 (95% CI 0.28-3.80). Conclusion: The levels of lipoprotein-a and lymphocyte neutrophil ratio were related to the clinical severity measured by NIHSS scale but not with hypertension.

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