The Current Management Advance Parkinson's Disease Focus on DBS Repository

The Current Management Advance Parkinson's Disease Focus on DBS

Muhammad Hamdan (2016) The Current Management Advance Parkinson's Disease Focus on DBS. In: The New era : Towards Curative Neurology. CV. Dwiputra Pustaka Jaya, Sidoarjo, pp. 421-431. ISBN 978-602-6604-02-6

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Abstract

Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor and non-motor symptoms, with a variable clinical progression. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) or globus pallidus pars internus (GPi) can dramatically improve the motor symptoms and quality of life of advanced PD patients. Stimulation of the STN has become the most frequently applied surgical procedure for DP, because treating neurologists and neurosurgeons consider it more efficient than pallidal stimulation. Subthalamic deep brain stimulation (STN DBS) is an established treatment for the motor symptoms in patients with advanced Parkinson's disease (PD). In addition to improvements in motor symptoms, many studies have reported changes in various nonmotor symptoms (NMSs) after STN DBS in patients with PD. Psychiatric symptoms, including depression, apathy, anxiety, and impulsivity, can worsen or improve depending on the electrical stimulation parameters, the locations of the stimulating contacts the STN, and changes in medications after surgery. Global cognitive function is not affected by STN BDS, and there is no increase in the incidence of dementia after STN DBS compared tothat after medical treatment, although clinically insignificant declines in verbal fluency have been consistently reported. Pain, especially PD-related pain, improves with STN DBS. Evidence regarding the effect of STN DBS on autonomic symptoms and sleep-related problems is limited and remains conflicting.

Item Type:

Book Section

Uncontrolled Keywords:

Deep Brain Stimulation, Management, Parkinson disease

Subjects:

R Medicine > R Medicine (General)
R Medicine > RA Public aspects of medicine

Divisions:

01. Fakultas Kedokteran > Ilmu Penyakit Saraf

Creators: