Paulus Sugianto and Aulanni'am and M. Aris Widodo and Mohammad Hasan Machfoed (2013) Neuroprotective Effect Of Citicholine In Mercury Intoxication. International Journal of Pharmaceutical Science Invention, 2 (11). pp. 38-44. ISSN 2319670X
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Abstract
Objective: Mercury induces cell death in various cell lines by apoptosis or necrosis. It is associated with alteration of some apoptosis regulators such as p53 and caspase-3. Citicholin has been widely used as neuroprotectant in cerebrovascular disease and other neurologic disorder. Previous studies have shown beneficial effect of citicholin in reducing inflammation and apoptosis in patient with stroke and pain, but none of those have used mercury intoxicated rat animal model. We try to investigate the neuroprotective effect of citicholin mercury intoxication. Methods : We conducted an controlled study using male rats (Rattus Novergicus) as animal model and devided the subjects into 5 groups (P0,P1,P2,P3,P4) and 0.4 mg/kg BW of MeHgCl3 is administered for 21 days to all groups. Citicholin (0,5,10,20 and 40 mg/kgBW/day was added during the exposure. Protein p53 and Caspase-3 expression on neurons were counted. Result : The mean scores±SD of p53 in group P0;P1;P2;P3;P4 were 8,406±0,70; 6,828±1,40; 4,680±1,2; 1,752±0,4; 0,807±0,1 respectively and for Caspase 3 were 8,854±1,91; 6.670±0,61; 4,21±1,02; 2,632±1,00; 0,818± 0,22 respectively. Conclusion : citicoline treatment exerts neuroprotective effect against neuronal apoptotic changes by reducing the expression of p53 and caspase-3 in dose dependent manner on mercury intoxicated rat.
| Item Type: | Article | ||||||||||
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| Uncontrolled Keywords: | mercury, citicoline, p53, caspase-3 | ||||||||||
| Subjects: | R Medicine > R Medicine (General) R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
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| Divisions: | 01. Fakultas Kedokteran > Ilmu Penyakit Saraf | ||||||||||
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| Depositing User: | arys fk | ||||||||||
| Date Deposited: | 30 Aug 2020 14:06 | ||||||||||
| Last Modified: | 30 Aug 2020 14:06 | ||||||||||
| URI: | http://repository.unair.ac.id/id/eprint/97837 | ||||||||||
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