Paulus Sugianto and Roudlotul Anggraini and Widjiati and Anwar Ma'ruf (2013) Effect of cdp-choline to reduce the amount of necrosis fibrouse astrocyte in cerebral medula of white rats (rattus novergicus) exposed by methylmercury. Veterinaria Medika, 6 (3). pp. 185-188. ISSN 1979-1306

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Abstract

The aim of this research was to find out the amount of necrotic fibrous astrocyte that exposed by methylmercury (II) chloride in 30 days, then treated by CDP Choline in 14 days. Before treatment is given,the white rats randomly divided into 5 groups, and every treatment consist of 5 repetitions. All groups weregiven treatment per oral with sonde. P0 as control were given 0.5 ml aquades in 30 days, P1 were given methylmercury(II)chloride 0,02 mg/kg/bw in 30 days, P2 were methylmercury (II) chloride 0,04 mg/kg/bw 30 days, P3 were given methylmercury (II) chloride 0,02 mg/kg/bw in 30 days, then treated by CDP-Choline100mg/kg/bw in 14 days, P4 were given methylmercury(II)chloride 0,04 mg/kg/bw in 30 days, then treated by CDP-Choline 100mg/kg/bw in 14 days. The data was analyzed by ANOVA and to analyze the meandifferences among treatments tested by Duncan's multiple range (Duncan's Multiple Range Test). Results that the amount of necrosis fibrous astrocyte had a significant differences between P0, P1, P3 with P2 and P4.The amount of necrotic fibrous astrocyte in P1 is higher than P3, as well as withthe P2group, that showedthehighest amount of necrotic fibrousastrocytes, when compared with P2, was seen reduction in the amount of necrotic fibrous astrocytes. The conclusion from this study is CDP-choline 100 mg/kg/bw can decrease the amount of necrotic fibrous astrocytes that have been exposed to methylmercury(II) chloride at a dose of 0.02 and 0.04 mg/kg/bw.

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