Belinda Handi Puspita (2020) Prediksi Kelarutan Dan Laju Disolusi Pembentukan Kokristal Asam P- Metoksisinamat (Apms)-Kafein Dengan Metode Penguapan Pelarut. Skripsi thesis, UNIVERSITAS AIRLANGGA.
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Abstract
p-methoxy cinnamic acid (pMCA) is an ester-type compound that works like NSAIDs (NonSteroidal Anti-Inflammatory Drugs). pMCA has anti-inflammatory, hepatoprotective, antidiabetic, antihyperglycemic, and analgesic activities. pMCA has 0.712 mg/mL solubility at 25°C, which means that it is very difficult to dissolve. Low solubility can affect to low bioavailability of pMCA. One of the methods that can be used to increase its solubility is the formation of cocrystal (cocrystallization). Cocrystallization requires coformer that can form noncovalent bonds with pMCA. Caffeine has a carbonyl group which has the potential to form hydrogen bonds with carboxylate in pMCA. This study aims to determine the effect of the formation of pMCA-caffeine cocrystal prepared by solvent evaporation method with 1:1 ratio on the solubility and dissolution rate, through prediction from literature studies based on the characterization data that has been obtained. Characterization of cocrystal was performed using Differential Scanning Calorimetry (DSC), Powder X-Ray Diffraction (PXRD) and Scanning Electron Microscope (SEM). The results of characterization using DSC showed that the melting point of cocrystal (155.09°C) is lower than pMCA (173.55°C) and caffeine (235.86°C). Compounds with low melting point have low intermolecular interactions and higher solubility. Characterization with PXRD showed a decrease in crystal lattice energy which resulted in increased solubility. The results of microphotograph using SEM showed formation of crystals with new morphology, where different morphology will affect the solubility of the crystals.
| Item Type: | Thesis (Skripsi) | |||||||||
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| Additional Information: | KKC KK FF.PA.10-20 Pus p | |||||||||
| Uncontrolled Keywords: | Para-Methoxy Cinnamic Acid, Caffeine, Cocrystal, Solvent Evaporation, Solubility | |||||||||
| Subjects: | R Medicine R Medicine > RS Pharmacy and materia medica |
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| Divisions: | 05. Fakultas Farmasi > Kimia Farmasi | |||||||||
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| Depositing User: | hardiansah pramana abdilah | |||||||||
| Date Deposited: | 15 Dec 2020 23:30 | |||||||||
| Last Modified: | 15 Dec 2020 23:30 | |||||||||
| URI: | http://repository.unair.ac.id/id/eprint/100880 | |||||||||
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