Prihartini Widiyanti and I. Sholikhah and A. Isfandiary and NAF. Hasbiyani and M. B. Lazuardi and R. D. Laksana (2017) Poly (1,8 Octanediol-co-Citrate) Hydroxyapatite Composite as Antibacterial Biodegradable Bone Screw. In: The 4th International Conference on Advanced Materials Science and Technology. IOP Conf. Series: Materials Science and Engineering, 202 (012082). IOP Publishing, pp. 1-8.

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Abstract

The high bone fracture rates reaching up to 300-400 cases per month have been treated with surgical procedure of internal fixation. Nevertheless, the commonly used metal screw has shown several weaknesses. Therefore, it is required bone screw of which primary characteristics include being biocompatible, bio-functional, biodegradable, and anticorrosive. The study aimed to synthesize Antibacterial Poly 1,8-Octanediol-co-Citrate (POC) and investigated the effect of chitosan on the antibacterial and compatibility characteristics of POC-HA composite as antibacterial biodegradable bone screw. The characterization were conducted on POC-HA composite to assess its functional cluster, antibacterial activity, cytotoxicity, degradation capacity, and morphology. Pre-polymer POC was composited with 62% nano-HA, followed by post-polymerization treatment. The sample then coated by chitosan with composition variations of 1%, 3%, and 5%. The nano-HA marked with the appearance of phosphate cluster on the wavenumber of 872.17 cm-1 and 559.51 cm-1, while the chitosan marked with C=O stretch cluster of esther at 1729 cm-1 from Fourier Transform InfraRed (FTIR) measurement. The best result was obtained with 3% chitosan coating. The POCHA composites showed bacterial inhibiting ability of 16.92 mm with non-toxic characteristics. These results indicated that chitosan coating Poly 1,8-Octanediol-co-Citrate (POC)-Nano Hydroxyapatite composite is a potential candidate for an antibacterial biodegradable bone screw.

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