Natasha Gebyta Fajrin (2020) Kajian Pelepasan Obat In Vitro Pada Sistem Penghantaran Obat Intravaginal Dari Penggunaan Beberapa Polimer Mukoadhesif : Literature Review. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Infections in femele reproduction system becomes disease that affects many women at productive ages every years. Treatment fot infection uses peroral drug delivery system that has many disadvantages. Reseacher developed mucoadhesive preparations for intravaginal drug delivery system using mucoadhesive polymer. Mucoadhesive polymers and interect with vaginal mucosa and can swell to modify the drug release. The aim of this reseach is to investigate the effect of the use of mucoadhesive polymer for drug release in intravaginal drug preparation and to determine mucoadhesive polumers that can be recommended for the development of intravaginal drug delivery system. This reseach is a scooping review, by reviewing published articels in online search engine, PubMed. Chitosan, Carbopol, HPMC, and k-carrageenan are mucoadhesive used in intravaginal drug delivery systems. Based on the results of reviewing published articles, HPMC can prolong the drug release. Use of HPMC and k-carrageenan combination can also prolong the drug release.

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