Iwan Sahrial Hamid, - and Juni Ekowati, - and Muhammad Thohawi Elziyad Purnama, - (2019) Kaempferia galanga L. Inhibiting Effect on Vascular Endothelial Growth Factor (VEGF) and Cyclooxygenase-2 (Cox-2) Expression on Endothelium of Chorioallantoic Membrane. Indian Veterinary Journal, 96 (9). pp. 80-82. ISSN 0019-6479, E-ISSN 0974-9365

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Abstract

This study was aimed to examine the extractof Kaempferia galanga L. to inhibit the expres-sion of VEGF and Cox-2 on the chorioallantoicmembrane of embryonated chicken eggs (ECE).This study used 24 ECE which were dividedinto six groups: (C+) inoculated with solvent,(C-, T1, T2, T3 and T4) inoculated with bFGF60 ng then (T1, T2, T3 and T4) treated with theextract doses of 30, 60, 90 and celecoxib 60 mg,respectively. Expression of VEGF and Cox-2 wasobserved by the immunohistochemical method.It was concluded that the extract of Kaempferiagalanga L. can inhibit the expression of VEGFand Cox-2 on the chorioallantoic membrane Key words: Kaempferia galanga L, VEGF,Cox-2, celecoxib

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