Tasya Dentria Chiefianggi (2020) Ectopic Calcification in caALK2 mice. Skripsi thesis, UNIVERSITAS AIRLANGGA.

	Text (HALAMAN JUDUL) 1. HALAMAN JUDUL.pdf Download (863kB)
	Text (ABSTRACT) 2. ABSTRACT.pdf Download (515kB)
	Text (TABLE OF CONTENTS) 4. TABLE OF CONTENTS.pdf Download (522kB)
	Text (CHAPTER 1 INTRODUCTION) 5. CHAPTER 1 INTRODUCTION.pdf Download (522kB)
	Text (CHAPTER 2 LITERATURE REVIEW) 6. CHAPTER 2 LITERATURE REVIEW.pdf Restricted to Registered users only until 9 June 2024. Download (610kB) | Request a copy
	Text (CHAPTER 3 RESEARCH METHODOLOGY) 7. CHAPTER 3 RESEARCH METHODOLOGY.pdf Restricted to Registered users only until 9 June 2024. Download (543kB) | Request a copy
	Text (CHAPTER 4 RESULTS) 8. CHAPTER 4 RESULTS.pdf Restricted to Registered users only until 9 June 2024. Download (965kB) | Request a copy
	Text (CHAPTER 5 DISCUSSION) 9. CHAPTER 5 DISCUSSION.pdf Restricted to Registered users only until 9 June 2024. Download (623kB) | Request a copy
	Text (CHAPTER 6 CONCLUSION AND SUGGESTION) 10. CHAPTER 6 CONCLUSION AND SUGGESTION.pdf Restricted to Registered users only until 9 June 2024. Download (515kB) | Request a copy
	Text (REFERENCES) 11. REFERENCES.pdf Restricted to Registered users only Download (590kB) | Request a copy
	Text (PERMOHONAN EMBARGO) PERMOHONAN EMBARGO.pdf Restricted to Registered users only Download (227kB) | Request a copy

Abstract

Background: Ectopic calcification can arises from several complicated diseases such as Fibrodysplasia Ossificans Progressiva (FOP). FOP is a rare congenital disorder of progressive and widespread ectopic classification which can extends to skeletal muscles and adjacent connective tissues. A caALK2 mouse model which resembling FOP condition has been established from previous studies, but the development of ectopic calcification is still inadequate for further research of drug candidates. A suitable and appropriate condition to develop ectopic calcification is needed to promote future studies. Objective: To investigate the appropriate condition to develop ectopic calcification in caALK2 mice for future studies. Methods: caALK2 transgenic mice were generated and obtained from Tokyo, then tested by genotyping to confirm the occurrence of recombination. Ad.Cre and cardiotoxin then injected to the target tibia to induce the ectopic calcification. Further evaluation are done through micro CT imaging, immunohistochemistry and data analysis. Result: Cre recombination is successfully occurred and ectopic calcification is successfully developed through the induction of Ad.Cre. Conclusion: An inducing factor such as Ad.Cre and an appropriate dose of injection is needed in order to create a suitable condition to develop ectopic calcification.

Item Type:	Thesis (Skripsi)
Additional Information:	KKA KK KG 131/21 Chi e
Uncontrolled Keywords:	ectopic calcification, caALK2, FOP, Ad.C
Subjects:	R Medicine > RA Public aspects of medicine > RA1-1270 Public aspects of medicine > RA421-790.95 Public health. Hygiene. Preventive medicine > RA643-645 Disease (Communicable and noninfectious) and public health
Divisions:	02. Fakultas Kedokteran Gigi
Creators:	Creators NIM Tasya Dentria Chiefianggi C160251
Contributors:	Contribution Name NIDN / NIDK Thesis advisor Kotaro Tanimoto NIDN-
Depositing User:	sukartini sukartini
Date Deposited:	09 Jun 2021 07:08
Last Modified:	09 Jun 2021 07:08
URI:	http://repository.unair.ac.id/id/eprint/107647
Sosial Share:

Actions (login required)

View Item