Achmad Naufal Maulana Akbar (2020) Uji Aktivitas Antidiabetes Granul Campuran Ekstrak Kulit Buah Manggis (Garcinia mangostana) Dan Daun Kumis Kucing (Orthosiphon Stamineus) Dengan Metode Induksi Aloksan Literature Review. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Diabetes mellitus is a metabolic disorder characterized by an increase glucose levels in the blood (hyperglycemia). This is associated with abnormalities in carbohydrate, fat and protein metabolism due to abnormalities in insulin secretion, insulin action (sensitivity) or both, from genetic and environmental factors and resulting in chronic complications including microvascular, macrovascular and chronic neuropathy. Mangosteen (Garcinia mangostana L.) and kumis kucing or cat whiskers (Orthosiphon stamineus Benth.) are original plants from Indonesia, which have been studied and have antidiabetic properties. Xanthones, α- mangostin, which is contained in the rind of mangosteen (G. mangostana L.) are known to have antidiabetic properties by stimulating insulin secretion in cells and maintaining a number of INS-1 cells at high glucose levels. In the cat's whiskers plant (Orthosiphon stamineus Benth.), the content of sinensetin as an antidiabetic effect has been shown to inhibit α- glucosidase and α-amylase, which have the potential to be effective therapy in post prandial hyperglycemia in type 2 diabetes mellitus. In this literature review was carried out in a scoping review method regarding the antidiabetic activity of the extract combination of mangosteen (G. mangostana L.) rind and cat's whiskers (O. stamineus Benth.) in alloxaninduced mice (Mus musculus). Literature studies were also conducted regarding the synergistic effect of the two plants in reducing blood sugar levels in diabetic experimental in vivo animals model. Data analysis was performed with the appropriate keywords and inclusion criteria.

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