Ramidha Syaharani, - (2020) Pengaruh Cammelia Sinensis (Teh Hijau) Dengan Bahan Aktif Egcg Terhadap Perubahan Jumlah Nekroptosis Sel Neuron Pada Rattus Norvegicus Model Middle Cerebral Artery Occlusion (MCAO). Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Introduction: Stroke is a sudden neurological deficit caused by focal brain injuryto the central nervous system by vascular causes. Stroke is in the 2nd position as anon-communicable disease that causes death. Oxidative stress play important rolein the pathology of neuronal cell death after ischemic stroke Objectives : To determine the effect of green tea with its active compound EGCGtowards decreasing number of neuronal necroptosisMethods: In vivo-study perform on male Rattus norvegicus MCAO model dividedinto 5 groups, control groups, EGCG 10 mg/kgBW/day, EGCG 20 mg/kgBW/day, EGCG 30 mg/kgBW/day, and green tea extract “Meditea” 30 mg/kgBW/day for 7days treatment. MCAO model made by modification method use Bulldog clamp.After 7 days of treatment, all Rattus norvegicus were sacrificed. After that, weexamined use H.E stain to look at number of neuronal necroptosis in each group. Results: We found that there are significant difference between control group and three later group (EGCG 20 mg/kgBW/day, EGCG 30 mg/kgBW/day, and Green Tea Extract (p<0,05). We found that there are no significant difference between control group and EGCG 10 mg/kgBW/day (p>0,05). There is no significant different in EGCG group compared to Green tea extract group (p>0,05). There is significant correlation between number of neuron cell necroptosis and both EGCG and Green trea extract (p<0,05). Correlation is negative which mean, both EGCG and Green trea extract will decrease number of neuron cell necroptosis. EGCG will decrease neuron cell necroptosis start with dose : 20 mg/kgBW/day . EGCG 30mg/kgBW/day produce best result compared to other dose. Conclusion: Camellia sinensis (green tea) with its active compound EGCG significantly decrease number of neuronal necroptosis in MCAO models

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