Topical Epigallocatechin-3-gallate Hydrogels Regulated Inflammation and Pain

Kun Ismiyatin, - and Soegeng Wahluyo, - and Retno Pudji Rahayu, - and Bambang Purwanto, - and Adioro Soetojo, - and Indri Safitri Mukono, - (2019) Topical Epigallocatechin-3-gallate Hydrogels Regulated Inflammation and Pain. Journal of International Dental and Medical Research, 12 (1). pp. 54-60. ISSN 1309-100X

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The aim of this study is to determine in vivo response of topical Epigallocatechin-3-gallate (EGCG) hydrogels to pain and inflammation through Toll-like receptor 4 (TLR4), Superoxide dismutase (SOD1), Prostaglandin E2 (PG-E2) and Transient receptor potential vanilloid 1 (TRPV1) in pulpal inflammation. Rats (n=35) were divided into a normal group (N), a positive control group induced with LPS for 6 hours (C1), a group induced with LPS for 24 hours (C2), a treatment group induced with LPS and topical EGCG 120 µg/ml (T1) for 6 hours and a group induced with LPS and topical EGCG 120 µg/ml for 24 hours (T2). Tissues were collected and observed by means of immunohistochemistry (IHC) to detect the expression of TLR4, SOD1, PG-E2 and TRPV1. Data were analyzed using a One-Way ANOVA test for TLR4, PG-E2 and TRPV1, while SOD1 was analyzed using a BrownForsythe test and Games Howell test. Application of topical 120 µg/ml EGCG hydrogels in tooth cavities at 6 hours and 24 hours pulpal inflammation significantly increased the expression of SOD1, while significantly decreasing the expressions of TLR4, PG-E2 and TRPV1 (P< 0.001). EGCG can be used as a pain inhibitor, anti-inflammatory agent and antioxidant agent against pulpal inflammation in rat models.

Item Type: Article
Uncontrolled Keywords: Topical EGCG, TLR4, SOD1, PG-E2, TRPV1
Subjects: R Medicine > R Medicine (General)
R Medicine > RA Public aspects of medicine
Divisions: 01. Fakultas Kedokteran > Ilmu Faal
Kun Ismiyatin, -NIDN0002046001
Soegeng Wahluyo, -NIDN0010115405
Retno Pudji Rahayu, -NIDN0014115906
Bambang Purwanto, -NIDN0028088001
Adioro Soetojo, -NIDN0010085102
Indri Safitri Mukono, -NIDN0014065303
Depositing User: arys fk
Date Deposited: 09 Feb 2022 07:42
Last Modified: 10 Feb 2023 08:00
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