Hery Suwito, .- and Noorma Kurnyawaty, .- and Ellyca Susetyo, .- and Yuzkiya Azizah, .- and Kautsar Ul Haq, .- and Alfinda Novi Kristanti, .- and Indriani Indriani, .- (2019) (E)-3-(2,5-Dimethoxyphenyl)-1-{[4-(2,5-dimethoxyphenyl)-6-((E)-2,5-dimethoxystyryl)-2-thioxo-1,2,3,4tetrahydropyrimidin-5-yl]}prop-2-en-1-one and (E)-3(2,5-Dimethoxyphenyl)-1-{[4-(2,5-dimethoxyphenyl)6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-5yl]}prop-2-en-1-one. Molbank, 2019 (2). pp. 1-8. ISSN 1422-8599

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Abstract

Dihydropyrimidine derivatives possess great potential to be used as a precursor for the synthesis of wide diverse dihydropyrimidine-like derivatives. In this research, the title compounds were synthesized through the reaction between 5-acetyl-4-(2,5-dimethoxyphenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-thione and 2,5-dimethoxybenzladehyde under aldol condensation condition. The title compound, (E)-3-(2,5-dimethoxyphenyl)-1-{[(4-(2,5-dimethoxyphenyl)-6-((E)-2,5-dimethoxystyryl)-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)]}prop-2-en-1-one (yield 15%), was obtained as major product, whereas (E)-3-(2,5-dimethoxyphenyl)-1-{[(4-(2,5-dimethoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro pyrimidin-5-yl)]}prop-2-en-1-one (yield 8%) as side product through vinylogous aldol condensation

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