Pinostrobin Isolate from Kaempferia Pandurata Roxb Induced Apoptosis in TD-47 Human Breast Cancer Cell Line

Sukardiman, - and Noor Cholies Zaini, - and Aty Widyawaruyanti, - and Sismindari, - and Rice Disi Oktarina, - Pinostrobin Isolate from Kaempferia Pandurata Roxb Induced Apoptosis in TD-47 Human Breast Cancer Cell Line. Laporan Penelitian. UNIVERSITAS AIRLANGGA, Surabaya.

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Abstract

Pinostrobin isolated from Koempferia pandurato Roxb which belongs to the family of Zingiberaceae, was observed to induce apoptosis in TD-47 human breast cancer cell line. Pinostrobin at 10 , 50 ,100 ug/ml for 24, 48 and 72 h induced DNA fragmentation and Increased the percentage of apoptotic cell after acridine orange - ethidium brornide staining. Our result demonstrated that andrographolide can induce apoptosis in in TD-47 human breast cancer cell line in a time and concentration dependent manner by increase expression of p53 , bax , caspase-3 and decreased expression of bc1-2 by immunohistochemical analysis.

Item Type: Monograph (Laporan Penelitian)
Additional Information: KKB LP.218-10 Pin
Uncontrolled Keywords: Pinostrobin, Kaempferia pondurata Roxb , TD-47 cell , Apoptosis, p53
Subjects: R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi > Ilmu Kefarmasian
Creators:
CreatorsNIM
Sukardiman, --
Noor Cholies Zaini, --
Aty Widyawaruyanti, --
Sismindari, --
Rice Disi Oktarina, --
Depositing User: S.Sos. Sukma Kartikasari
Date Deposited: 20 Apr 2022 02:28
Last Modified: 20 Apr 2022 02:28
URI: http://repository.unair.ac.id/id/eprint/115619
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