Alfarius Eko Nugroho, - and Yurika Ono, - and Eunji Jin, - and Yusuke Hirasawa, - and Toshio Kaneda, - and Abdul Rahman, - and Idha Kusumawati, - and Takahiro Tougan, - and Toshihiro Horii, - and Noor Cholies Zaini, - and Hiroshi Morita, - (2021) Bisindole alkaloids from Voacanga grandifolia leaves. Journal of Natural Medicines, 75 (1). pp. 408-814. ISSN 1340-3443

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Abstract

Two new bisindole alkaloids, 12′-O-demethyl-vobtusine-5-lactam and isovobtusine-N-oxide (1 and 2), were isolated from the leaves of Voacanga grandifolia, together with two known bisindole alkaloids. Their structures were elucidated on the basis of 1D and 2D NMR data. 1 and 2 showed potent antimalarial activity against Plasmodium falciparum 3D7 and very low cytotoxic activity against a human cell line, HepG2 cells.

Item Type:	Article
Uncontrolled Keywords:	Voacanga grandifolia, Bisindole alkaloids, Apocynaceae, Antimalarial activity
Subjects:	R Medicine R Medicine > RS Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS200-201 Pharmaceutical dosage forms
Divisions:	05. Fakultas Farmasi > Farmakognosi Fitokimia
Creators:	Creators NIM Alfarius Eko Nugroho, - - Yurika Ono, - - Eunji Jin, - - Yusuke Hirasawa, - - Toshio Kaneda, - - Abdul Rahman, - - Idha Kusumawati, - NIDN0004087003 Takahiro Tougan, - - Toshihiro Horii, - - Noor Cholies Zaini, - - Hiroshi Morita, - -
Depositing User:	Mr M. Fuad Sofyan
Date Deposited:	08 Jul 2022 06:57
Last Modified:	26 Mar 2023 07:49
URI:	http://repository.unair.ac.id/id/eprint/117005
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