Muchammad Manhum Mawarid, - and Maslichah Mafruchati, - and Tri Wahyu Suprayogi, - and Widjiati, - and Viski Fitri Hendrawan, - and Epy Muhammad Luqman, - Potency of Kebar Grass (Biophytum petersianum) Extract to Histopathological of Mice (Mus musculus) Duodenum at Lactation Period Exposed to Carbofuran. Journal of Veterinary and Marine Research, 11 (1). pp. 1-9. ISSN 2689-7830

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Abstract

This research was aimed to find out the effect of the Kebar grass extract on a decrease in villi damage in the duodenum of mice at lactation period due to exposure to carbofuran such as congestion, edema, and neutrophil infiltration. This research used forty-two mice at lactation period, divided into seven treatment groups, each group consisting of six mice. The treatment groups consisted of C (aquadest); T1 carbofuran 0.0125 mg (1/4 LD50); T2 carbofuran 0.00625 mg (1/8 LD50); T3 Kebar grass extract 3,375 mg + carbofuran 1/4 LD50; T4 Kebar grass extract 3.375 mg + carbofuran 1/8 LD50; T5 vitamin C 5 mg + carbofuran 1/4 LD50; and T6 vitamin C 5 mg + carbofuran 1/8 LD50. All groups were treated for 14 days and on day 15 all mice were slaughtered for histopathological observation on their duodenum. The data were analyzed using the Kruskal-Wallis test and the Mann-Whitney test with a significance of p<0.05. The results showed that carbofuran administration could increase congestion, edema, and neutrophil infiltration (p<0.05). The administration of Kebar grass extract was proven to reduce congestion, edema, and neutrophil infiltration and a decrease in congestion, edema, and neutrophil infiltration was better when it was administered Kebar grass extract compared to vitamin C (p<0.05)

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