Sri Purwaningsih (2004) Efek Perlindungan Antioksidan Probucol terhadap Terjadinya Nefropati Diabetik pada Mencit : Penelitian Eksperimental Laboratorik. Thesis thesis, UNIVERSITAS AIRLANGGA.
![[img]](https://repository.unair.ac.id/style/images/fileicons/text.png) |
Text (COVER)
KKA KK TKD 11_05 Pur e_COVER.pdf Download (889kB) |
|
Text (DAFTAR ISI)
KKA KK TKD 11_05 Pur e_DAFTAR ISI.pdf Download (568kB) |
|
Text (ABSTRACT)
KKA KK TKD 11_05 Pur e_ABSTRACT.pdf Download (153kB) |
|
Text (BAB 1)
KKA KK TKD 11_05 Pur e_BAB 1.pdf Download (786kB) |
|
Text (BAB 2)
KKA KK TKD 11_05 Pur e_BAB 2.pdf Download (5MB) |
|
Text (BAB 3)
KKA KK TKD 11_05 Pur e_BAB 3.pdf Download (435kB) |
|
Text (BAB 4)
KKA KK TKD 11_05 Pur e_BAB 4.pdf Download (835kB) |
|
Text (BAB 5)
KKA KK TKD 11_05 Pur e_BAB 5.pdf Download (1MB) |
|
Text (BAB 6)
KKA KK TKD 11_05 Pur e_BAB 6.pdf Download (1MB) |
|
Text (BAB 7)
KKA KK TKD 11_05 Pur e_BAB 7.pdf Download (254kB) |
|
Text (DAFTAR PUSTAKA)
KKA KK TKD 11_05 Pur e_DAFTAR PUSTAKA.pdf Download (653kB) |
|
Text (LAMPIRAN)
KKA KK TKD 11_05 Pur e_LAMPIRAN.pdf Download (654kB) |
Abstract
Diabetes mellitus ts a metabolic syndrome with dyslipidernia, atherosclerotic and procoagulant state, and became primary cause of rnacrovascular and microvascular disturbances. One of microvascular disorder, namely endothelial dysfunction, became suspected primary cause of pathogenesis of diabetic nephropathy, which can further contribute to renal failure and has high mortality rate. Probucol is a lipophilic antioxjdant agent which has ability to protect and prevent LDL oxidation, lipid peroxidation on cell membranes, and to reduce superoxyde free radical level in the target tissues and cholesterol level in the blood. The aim of this research was to study the preventive effects of Probucol against renal structure changes on diabetic mice. The diabetic mice was made by injecting of alloxan monohydrate 140 Mg/bw intraperitoneally. Whole experimental animals were divided randomly to be control group, and the treated group. Each group used in this experiment consisted of 10 animals. All the treated animals given Probucol for 28 days. On the 29th day, all animals were decapitized and otopsy was done for histopathologic examination. The results of the experiments showed that the tltickness of basalis membrane of glomerulus, happened on the treated animals (85% more thicker than control animals), but did not on the control animals. From statistical analysis, showed that these differences were very significant (P < 0.05), and seemed that there was a liniar correlation between dosage of Probucol and the thickness of basalis membranes of glomerulus. Much ltigher dose used, more protected effects were found, especially in reducing of the thickness of basalis membranes of glomerulus.
| Item Type: | Thesis (Thesis) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Additional Information: | KKA KK TKD 11/05 Pur e | |||||||||
| Uncontrolled Keywords: | Diabetic nephropathy, Antioxidant effects, Probucol | |||||||||
| Subjects: | R Medicine > RC Internal medicine | |||||||||
| Divisions: | 01. Fakultas Kedokteran > Magister Ilmu Kedokteran Dasar | |||||||||
| Creators: |
|
|||||||||
| Contributors: |
|
|||||||||
| Depositing User: | Sulistiorini | |||||||||
| Date Deposited: | 14 Mar 2023 01:56 | |||||||||
| Last Modified: | 14 Mar 2023 01:56 | |||||||||
| URI: | http://repository.unair.ac.id/id/eprint/120519 | |||||||||
| Sosial Share: | ||||||||||
Actions (login required)
 |
View Item |