Bilqis Inayatillah, Bilqis and Tamam Jauhar, Tamam and Gondo Mastutik, Gondo and Alphania Rahniayu, Alphania Hypoglycemic Effects of Rosa damascena Mill. Ethanolic Extract on Blood Glucose Levels and Diameter of Langerhans Pancreatic Islets. Indian Journal of Forensic Medicine & Toxicology, 15 (2). ISSN p-0973-9122 and e-0973-9130

	Text (Artikel) C11 Artikel Hypoglycemic Effects of Rosa_compressed.pdf Download (3MB)
	Text (Laik Etik) C11 Etik Hypoglycemic Effects of Rosa.pdf Download (665kB)
	Text (Kualitas Karil & Kesesuaian Bidang Ilmu) C11 PAK 1.pdf Download (340kB)
	Text (Turnitin) C11 Turnitin Hypoglycemic Effects of Rosa.pdf Download (3MB)
	Text (Kualitas Karil & Kesesuaian Bidang Ilmu) 17 karil.pdf Download (193kB)

Abstract

Abstract Background: Diabetes mellitus is a chronic disorder caused by elevated levels of high blood glucose (hyperglycemia). This chronic hyperglycemia causes ROS to accumulate and oxidative stress to increase. Rosa damascena is a plant that contains high levels of antioxidants and polyphenols, but this is not widely known to the public. Purpose: The aim of this study is to understand the hypoglycemic effects from Rosa damascena on blood glucose levels and diameter of Langerhans pancreatic islets. Method: Thirty Wistar albino rats (200-225gr) were divided into 6 groups. Group 1 was a normal control (KN), group 2 was hyperglycemic (KD), group 3 was metformin 250 mg/kg BW (KM), group 4 was treatment extract 250 mg/ kg BW (P1), group 5 was treatment extract 500 mg/kg BW (P2) group 6 was treatment extract 1000 mg/ kg BW (P3). All animals in the group were injected with STZ 50 mg/kg BW, except for group 1. Result: Data were analyzed statistically using SPSS- 22 software with the Kruskall-Wallis test (p<0.05). The result showed that ethanolic extract of Rosa damascena has decreased blood glucose levels in days-14 (382 ±21,97) with 250 mg/kg BW (P1) compare with another treatment group. In histological observed there are no significant different between group (p>0.05). This is showing that ethanolic extract of Rosa damascena has inability to repaired the diameter of Langerhans pancreatic islets. Conclusion: Ethanolic extract of Rosa damascena decreased blood glucose levels but did not repaired the diameter of Langerhans pancreatic islets.

Actions (login required)

View Item