Amirah Azzeri, - and Mohd Noor Afiq Ramlee, - and Mohd Iqbal Mohd Noor, - and Mohd Hafiz Jaafar, - and Thinni Nurul Rochmah, - and Maznah Dahlui, - (2022) Economic Burden of SARS-CoV-2 Patients with Multi-Morbidity: A Systematic Review Protocol. International Journal of Environmental Research and Public Health, 19 (20). pp. 1-11. ISSN 1660-4601

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Abstract

Economic burden issues in SARS-CoV-2 patients with underlying co-morbidities are enormous resources for patient treatment and management. The uncertainty costs for clinical management render the healthcare system catatonic and incurs deficits in national annual budgets. This article focuses on systematic steps towards selecting and evaluating literature to uncover gaps and ways to help healthcare stakeholders optimize resources in treating and managing COVID-19 patients with multi-morbidity. A systematic review of all COVID-19 treatment procedures with co-morbidities or multi-morbidity for the period from 2019 to 2022 was conducted. The search includes studies describing treatment costs associated with multi- or co-morbidity cases for infected patients and, if concurrently reported, determining recurring expenses. Study selection will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Galbraith plots and I 2 statistics will be deployed to assess heterogeneity and to identify potential sources. A backward elimination processwill be applied in the regressionmodelling procedure. Based on the number of studies retrieved and their sample size, the subgroup analysis will be stratified on participant disease category, associated total costs, and degree of freedom in cost estimation. These studies were registered in the PROSPERO registry (ID: CRD42022323071).

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