Tania Saskianti, - and Aisyah Novianti, - and Diina Sahar, - and Alexander Patera Nugraha, - and Tansza Setiana Putri, - and Masami Kanawa, - and Mega Moeharyono Puteri, - and Ardianti Maartrina Dewi, - and Diah Savitri Ernawati, - (2020) Mixed Polymethylmethacrylate and Hydroxyapatite as a Candidate of Synthetic Graft Materials for Cleft Palate. Journal of International Dental and Medical Research, 13 (2). ISSN 1309-100X

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Abstract

This research aimed to investigate scaffolds of mixed polymethylmethacrylate (PMMA) and hydroxyapatite (HA) that can be considered as a candidate of synthetic graft materials for cleft palate. Polymethylmethacrylate-hydroxyapatite (PMMA-HA) scaffold was done by weighing PMMA granules and HA powder for a 20:80, 30:70 and 40:60 ratio, that mixed and moulded in 5 mm of diameter and 10 mm of height, then freeze dried before being analyzed by X-Ray Diffraction (XRD), Fourier Transform Infra-Red (FTIR), Scanning electron microscope (SEM) and Energy dispersive X-ray (EDX) instruments. XRD analysis in 20:80, 30:70 and 40:60 ratio has a peak that represents HA and an amorphous peak that represents PMMA, with the best ratio is 30:70.FTIR analysis showed the existence of HA functional groups namely phosphate (PO43-), calcium carbonate (CO32-), and hydroxyl (OH-) in all three samples, with 20:80 ratio as the optimal composition. SEM observation showed visible interconnected pores and roughness, also various pore sizes that averaged by 278.71µm; 312.3µm; 332.8µm, and 1.267µm; 1.716µm; 1.951µm, that showed by 50x and 5000x magnification, with 20:80 ratio as the ideal environment. EDX analysis showed Calsium (Ca), Oxygen (O), Phosphate (P), Silicate (Si), and Aluminium (Al) contained in the PMMA-HA sample, with 20:80 ratio as the highest potention to osteoblast regeneration. PMMA-HA scaffold with 20:80 ratio considered as the best ratio to be a candidate of synthetic graft materials for cleft palate.

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