Febriastuti Cahyani, - and Widya Saraswati, - and Eric Priyo Prasetyo, - and Meircurius Dwi Condro Surboyo, - and Wibi Riawan, - and Karina Erda Saninggar, - and Ninuk Hariyani, - and Anisa Kusumawardani, - and Adioro Soetojo, - and Soetjipto, - (2022) The Effect of α-Mangostin on TLR-4 and PGE2 in the Dentin-Pulp Complex Exposed to HEMA. Journal of International Dental and Medical Research, 15 (1). pp. 21-26. ISSN 1309-100X

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Abstract

Mangosteen is abundant in Indonesia. Most mangosteen pericarp contains Alpha (α) mangostin, which has numerous biological benefits, especially antioxidant, antibacterial and antiinflammatory properties. The purpose of this study is to analyse the effect of α-mangostin on tolllike receptor 4 (TLR-4) and prostaglandin E2 (PGE2) in vivo. An in vivo study was conducted using 42 male Wistar rats (Rattus norvegicus) in randomised post-test control groups. The rats were divided into a control group applied 2-hydroxyethyl methacrylate (HEMA) and a treatment group applied HEMA and 12,5µg/ml of α-mangostin. The inflammatory factors on the dentin-pulp complex of the rat’s model were examined. TLR-4 was detected via immunohistochemistry and PGE2 was assayed via ELISA after 24, 48 and 72 hours. In vivo results showed a decrease in TLR-4 and PGE2 after α-mangostin treatment. Recent studies have shown that α-mangostin can significantly decrease TLR-4 and PGE2 on a dentin-pulp complex after exposure to HEMA.

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