Eka Arum Cahyaning Putri, Eka and Misbakhul Munir, Misbakhul and Hayuris Kinandita Setiawan, Hayuris and Lilik Herawati, Lilik and Gadis Meinar Sari, Gadis and Citrawati Dyah Kencono Wungu, Citrawati and Hendri Susilo, Hendri and Henry Sutanto, Henry Adverse Cardiac Events Following mRNA COVID-19 Vaccination. Journal of Pharmacy & Pharmacognosy Research, 11 (1). pp. 76-100. ISSN 0719-4250

	Text (Artikel) 05 artikel.pdf Download (2MB)
	Text (Kualitas Karil & Kesesuaian Bidang Ilmu) 05 karil.pdf Download (619kB)
	Text (Turnitin) 05 turnitin.pdf Download (4MB)

Abstract

Abstract Context: Although have been proven able to control the prevalence of coronavirus disease-19 (COVID-19), Pfizer-BioNTech and Moderna COVID-19 vaccines are reported to have possible side effects on the heart. Aims: To know the magnitude of adverse events in the cardiac after messenger ribonucleic acid (mRNA)-based vaccination. Methods: An electronic search in PubMed, Web of Science, Scopus, and Ebsco/Cinahl was performed. The keywords were: “COVID-19 vaccine”, “SARS-CoV-2 vaccine”, “myocarditis”, “myopericarditis”, “pericarditis”, “myocardial infarction”, and “myocardial injury”. The electronic search was updated until March 2022. STATA/MP Statistical Software: Release 14 (StataCorp LLC, College Station, Texas) was used in this study to perform a meta-analysis of a random-effect for myocarditis, pericarditis, myocarditis, myocardial infarction, and myocardial injury. Results: Twenty-one case reports/case series studies with a total of 62 individuals who had been vaccinated against COVID-19 mRNA (Pfizer-BioNTech and Moderna) were included in the systematic review. Whereas seven observational cohort studies had 170,053,333 people who had been vaccinated, 245 of whom had myocarditis. In addition, two observational cohort studies with 13,948,595 vaccinated individuals, 16 of whom developed pericarditis. There was only one observational cohort study that had a total of 7,183,889 people who had been vaccinated and 11 had myopericarditis. Based on the pooled incidence, the result is <0.002%. Conclusions: The Pfizer-BioNTech and Moderna vaccines have a low incidence of myocarditis. Men are more likely to develop post-COVID-19 myocarditis with an average age of 22 years and in the age range of 21-40 years. The type of mRNA COVID-19 vaccine that causes myocarditis the most is Pfizer. The diagnosis of myocarditis is mostly made by troponin examination. COVID-19 mRNA vaccination has a low incidence of myocarditis.

Item Type:	Article
Subjects:	R Medicine > R Medicine (General) > R5-920 Medicine (General)
Divisions:	01. Fakultas Kedokteran > Ilmu Faal
Creators:	Creators NIM Eka Arum Cahyaning Putri, Eka UNSPECIFIED Misbakhul Munir, Misbakhul NIM011714553015 Hayuris Kinandita Setiawan, Hayuris NIDN0007068204 Lilik Herawati, Lilik NIDN0014037509 Gadis Meinar Sari, Gadis NIDN0004056612 Citrawati Dyah Kencono Wungu, Citrawati NIDN0022128803 Hendri Susilo, Hendri NIM 011528136304 Henry Sutanto, Henry UNSPECIFIED
Depositing User:	arys fk
Date Deposited:	20 Apr 2023 05:05
Last Modified:	20 Apr 2023 05:05
URI:	http://repository.unair.ac.id/id/eprint/124033
Sosial Share:

Actions (login required)

View Item