Elyas Nattagh-Eshtivani, - and Naseh Pahlavani, - and Golnaz Ranjbar, - and Jamshid Gholizadeh Navashenaq, - and Ammar Salehi-Sahlabadi, - and Trias Mahmudiono, - and Mohammed Nader Shalaby, - and Mohammadhassan Jokar, - and Mohsen Nematy, - and Hanieh Barghchi, - and Shahrzad Havakhah, - and Mona Maddahi, - and Mohammad Rashidmayvan, - and Maryam Khosravi, - (2022) Does propolis have any effect on rheumatoid arthritis? A review study. Food Science and Nutrition, 10 (4). pp. 1003-1020. ISSN 20487177

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Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune disease in which inflammation and oxidative stress play a key role in its pathophysiology. Complementary therapies along with medications may be effective in the control of RA. Propolis is a natural substance extracted from beehives, which have confirmed anti-inflammatory and antioxidant effects. The present study aimed to review the possible effects of propolis on inflammation, oxidative stress, and lipid profile in patients with RA. English articles in online databases such as PubMed‑Medline, AMED, Google Scholar, EMBASE, Scopus, and Web of Science databases were searched. Pieces of evidence show that supplementation with propolis may have therapeutic effects on RA patients. Due to increased inflammation and oxidative stress in the affected joints of RA patients, propolis could inhibit the inflammatory cascades by inhibiting the nuclear factor kappa B pathway and reducing reactive oxygen species, malondialdehyde, and interleukin-17 by increasing some antioxidants. Therefore, inflammation and pain reduce, helping improve and control RA in patients. Further investigations are required with larger sample sizes and different doses of propolis to demonstrate the definite effects of propolis on various aspects of RA.

Item Type:	Article
Subjects:	R Medicine
Divisions:	10. Fakultas Kesehatan Masyarakat > Gizi Kesehatan
Creators:	Creators NIM Elyas Nattagh-Eshtivani, - - Naseh Pahlavani, - - Golnaz Ranjbar, - - Jamshid Gholizadeh Navashenaq, - - Ammar Salehi-Sahlabadi, - - Trias Mahmudiono, - NIDN0024038105 Mohammed Nader Shalaby, - - Mohammadhassan Jokar, - - Mohsen Nematy, - - Hanieh Barghchi, - - Shahrzad Havakhah, - - Mona Maddahi, - - Mohammad Rashidmayvan, - - Maryam Khosravi, - -
Depositing User:	Tn Chusnul Chuluq
Date Deposited:	27 Apr 2023 05:40
Last Modified:	27 Apr 2023 05:40
URI:	http://repository.unair.ac.id/id/eprint/124991
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