Inactivation of HIV-1 Infection through Integrative Blocking with Amino Phenylboronic Acid Attributed Carbon Dots

Yu Yu Aung, .- and Alfinda Novi Kristanti, .- and Siti Qamariyah Khairunisa, .- and Nasronudin Nasronudin, .- and Mochamad Zakki Fahmi*, .- (2020) Inactivation of HIV-1 Infection through Integrative Blocking with Amino Phenylboronic Acid Attributed Carbon Dots. ACS Biomaterials Science & Engineering, 6 (8). pp. 4490-4501. ISSN 2373-9878

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Current antiretroviral HIV therapies continue to have problems related to procedural complications, toxicity, and uncontrolled side effects. In this study, amino phenylboronic acid-modified carbon dots (APBA-CDs) were introduced as a new nanoparticle-based on gp120 targeting that inhibits HIV-1 entry processes. Prolonged by simple pyrolysis for preparing carbon dots, this report further explores attributing amino phenylboronic acid on carbon dots, which prove the formation of graphene-like structures on carbon dots and boronic acid sites, thereby enabling the enhancement of positive optical properties through photoluminescent detection. Aside from performing well in terms of biocompatibility and low cytotoxicity (the CC50 reach up to 11.2 mg/mL), APBA-CDs exhibited superior capabilities in terms of prohibiting HIV-1 entry onto targeted MOLT-4 cells recognized by the delimitations of syncitia formation and higher ATP signal rather than bare carbon dots. The modified carbon dots also promote dual-action on HIV-1 treatment by both intracellularly and extracellularly viral blocking by combining with the Duviral drug, along with compressing p24 antigen signals that are better than APBA-CDs and Duviral itself.

Item Type: Article
Uncontrolled Keywords: carbon dot, amino phenylboronic acid, HIV-1, viral entry, blocking infection
Subjects: Q Science
Q Science > QD Chemistry
Q Science > QD Chemistry > QD450-801 Physical and theoretical chemistry
Divisions: 08. Fakultas Sains dan Teknologi > Kimia
Alfinda Novi Kristanti, .-UNSPECIFIED
Siti Qamariyah Khairunisa, .-UNSPECIFIED
Nasronudin Nasronudin, .-UNSPECIFIED
Mochamad Zakki Fahmi*, .-UNSPECIFIED
Depositing User: Mr Vega Andi Budiman
Date Deposited: 09 Jun 2023 05:39
Last Modified: 09 Jun 2023 05:39
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