Engineering the Surface of Ti3C2 MXene Nanosheets for High Stability and Multimodal Anticancer Therapy.

Chiranjeevi Korupalli*, .- and Kai-Long You, .- and Girum Getachew, .- and Akash S. Rasal, .- and Worku Batu Dirersa, .- and Mochamad Zakki Fahmi, .- and Jia-Yaw Chang, .- (2022) Engineering the Surface of Ti3C2 MXene Nanosheets for High Stability and Multimodal Anticancer Therapy. Pharmaceutics, 14 (2). pp. 2-14. ISSN 1999-4923

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The surface of Ti3C2 MXene nanosheets (TC NSs) was first modified with the antioxidants sodium ascorbate (SA) and dopamine (DA) (DSTC NS) to improve their stability in oxidative and hydration environments and thereby improve their bioapplications. This novel approach not only improved MXene stability by arresting oxidation but also increased the available functional groups for further functionalization with various biomolecules. The DSTC NSs were then sequentially conjugated with enzyme glucose oxidase (GOx) and photosensitizer Ce6 to render the obtained CGDSTC NSs with glucose starvation and photodynamic therapeutic properties and thus attain high efficiency in killing cancer cells through the cooperative effect. The as-synthesized CGDSTC NSs demonstrated tremendous photothermal effect with conversion efficiency of 45.1% and photodynamic (ROS generation) properties upon irradiation with 808 and 671 nm lasers. Furthermore, it was observed that the enzymatic activity of CGDSTC NSs increased upon laser irradiation due to enhanced solution temperature. During in vitro studies, the CGDSTC NSs exhibited cytocompatability to HePG2 and HeLa cells under nonstimulus conditions. However, they elicited more than 90% cell-killing efficiency in the presence of glucose and laser irradiation via the cooperative effect between starvation therapy and phototherapy. These results indicate that CGDSTC NSs could be used as potential therapeutic agents to eradicate cancers with no or few adverse effects. This surface modification approach is also simple and facile to adopt in MXene-based research.

Item Type: Article
Uncontrolled Keywords: MXenes; Ti3C2; surface modification; cancer therapy; phototherapy; starvation therapy; cooperative therapy
Subjects: Q Science
Q Science > Q Science (General)
Q Science > QD Chemistry
Q Science > QD Chemistry > QD450-801 Physical and theoretical chemistry
Divisions: 08. Fakultas Sains dan Teknologi > Kimia
Chiranjeevi Korupalli*, .-UNSPECIFIED
Girum Getachew, .-UNSPECIFIED
Akash S. Rasal, .-UNSPECIFIED
Worku Batu Dirersa, .-UNSPECIFIED
Mochamad Zakki Fahmi, .-UNSPECIFIED
Jia-Yaw Chang, .-UNSPECIFIED
Depositing User: Mr Vega Andi Budiman
Date Deposited: 10 Jun 2023 05:53
Last Modified: 10 Jun 2023 05:53
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