Andika P. Wardana, .- and Nanik S. Aminah, .- and Mochamad Zakki Fahmi,, .- and Alfinda N. Kristanti, .- and Haninda I. Zahrah, .- and Yoshiaki Takaya, .- and M. Iqbal Choudary, .- (2020) Nanoencapsulation of Syzygium polycephalum Extract Using Folate Modified κ-Carrageenan as Vehicles for Pronounced Anticancer Activity. Tropical Journal of Natural Product Research, 4 (11). pp. 945-952. ISSN 2616-0684 ; 2616-0692

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Abstract

S. polycephalum (Sp) is an important species of the genus Syzygium. 3,4,3'-tri-O-methyl ellagic acid obtained from Sp, has potential as a natural anticancer agent. The drawback of natural products as medicine is their non-specific effects and poor solubility, so a better drug delivery system is needed to overcome this challenge. This study utilizes κ-carrageenan and carrageenan folate (Cf) as the carrier matrix. Sp-CNPs and Sp-CfNPs can increase the anticancer activity of Sp extract. The addition of folate groups to carrageenan gave better results in delivering the Sp extract drug on the HeLa cell line and T47D cell line. The free Sp extract was able to inhibit the growth of HeLa cancer cells with EC50 114.19 ± 10.31 μg/mL, while both Sp-CNPS and SpCfNPs nanocapsules showed EC50 79.19 ± 13.96 μg/mL and EC50 48.77 ± 15.91 μg/mL. In T47D cells, the free Sp extract showed EC50 498.33 ± 110.72 μg/mL. Sp-CNP nanocapsules were able to increase the anticancer activity of free Sp extract with EC50 80.62 ± 12.59 μg/mL, whereas Sp-CfNP performed anticancer activity against T47D cells with EC50 48.52 ± 2.76 μg/mL.

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