Etty Hary Kusumastuti, - and Priangga Adi Wiratama, - and Grace Ariani, - and Stephanie Natasha Djuanda, - and Alphania Rahniayu, - and Nila Kurniasari, - and Dyah Fauziah, - and Anny Setijo Rahaju, - and Isnin Anang Marhana, - and Alfian Nur Rosyid, - and Dwi Wahyu, - and Gilang Muhammad Setyo Nugroho, - and Adhitri Anggoro, - and I Komang Rusgi Yandi, - and Bambang Pujo Semedi, - and Jilientasia Godrace Lilihata, - and Ummi Maimunah, - and Supriadi, - and Achmad Lefi, - and Lalu Galih Pratama Rinjani, - and Edi Suyanto, - and Ricardo Ardian Nugraha, - (2022) Differences in interleukin-6 and interleukin-17 expression in covid-19 post-mortem lung tissue biopsy compared with noncovid- 19. Pharmacogn Jurnal, 14 (6). pp. 887-892. ISSN 9753575

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Abstract

Abstract: Background: COVID-19 has spread rapidly around the world. It is necessary to study lung tissue of postmortem COVID19 patients to determine the molecular alteration particularly the role of IL-6 and IL-17 in causing fatality. Objective: This study aims to determine the differences in the expressions of IL-6 and IL-17 in lung tissue of post-mortem COVID-19 patients compared to non-COVID-19 patients. This study also aimed to analyze the correlation between the expressions of IL-6 and IL-17 in lung tissue of post-mortem COVID-19 patients. Methods: This research is an observational analytic study with crosssectional approach. The samples were 15 paraffin blocks of post-mortem lung tissue biopsy of COVID-19 patients, and 15 paraffin blocks of inflammatory lung tissue biopsy or surgery of non-COVID-19 patients. IL-6 and IL-17 expressions were evaluated by immunohistochemical procedure. Result: There was a significant difference in the expression of IL-6 in the COVID-19 group and the non-COVID-19 group with a p-value = 0.001 (p < 0.05). There was a significant difference in the expression of IL-17 in the COVID-19 group and the non-COVID-19 group with p-value = 0.001 (p < 0.05). There was a significant correlation between the expressions of IL-6 and IL-17 in the COVID-19 group, with the Spearman coefficient value (rs) of 0.548 with p = 0.034 (p < 0.05). Conclusion: There are differences in the expression of IL-6 and IL-17 between COVID-19 and non-COVID-19 lung tissue. There is a significant correlation between the expressions of IL-6 and IL-17 in post-mortem lung tissue of COVID-19 patients.

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