Agustinus Vincent, - and Bramantono, - and Usman Hadi, - and Muhammad Vitanata Arfijanto, - (2021) Expanded Dengue Syndrome. Current Internal Medicine Research and Practice Surabaya Journal (CIMRJ), 2 (1). pp. 26-32. ISSN 2721-544X

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Abstract

Dengue viral infection (DVI) is a debilitating arthropod-borne disease that has been rapidly spread in several regions of the world in recent years. The spectrum of the disease varies from mild self-limiting illness to dengue fever (DF) to more severe and fulminating forms, i.e., dengue hemorrhagic fever (DHF), dengue shock syndrome (DSS), and expanded dengue syndrome (EDS). The pathogenesis of EDS is not clear amid the lack of studies on animal models. In the absence of in vitro experiments, the disease spectrum is challenging to elucidate and mimic for humans. Recent advances in research on atypical complications of EDS demonstrate the involvement of other major organs such as the kidney, lung, heart, and central nervous system. Histopathological findings demonstrate the presence of hemorrhage, edema, and inflammatory infiltrates in these organs. The spectrum of Dengue viral infection varies from mild self-limiting illness to dengue fever to more severe and fulminating forms, i.e., dengue hemorrhagic fever, dengue shock syndrome, and expanded dengue syndrome. Apart from the classical presentation, dengue infection can result in a myriad of unusual clinical manifestations grouped under the title expanded dengue syndrome. These findings urge more focused and comprehensive investigations to explore such relationships so that high-risk patients could be identified immediately during their presentation to the hospitals.

Item Type:	Article
Uncontrolled Keywords:	Expanded dengue syndrome, Pathogenesis, Organ-specific manifestation
Subjects:	R Medicine > RC Internal medicine > RC31-1245 Internal medicine
Divisions:	01. Fakultas Kedokteran > Ilmu Penyakit Dalam
Creators:	Creators NIM Agustinus Vincent, - UNSPECIFIED Bramantono, - NIDN8886800016 Usman Hadi, - NIDN8830230017 Muhammad Vitanata Arfijanto, - NIDN0015097112
Depositing User:	Miftachul Miftachul Mujayanah Mifta
Date Deposited:	11 May 2023 22:18
Last Modified:	11 May 2023 22:18
URI:	http://repository.unair.ac.id/id/eprint/126569
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