Ni Made Millania Laksmi Dewi, - (2022) Uji Aktivitas Peningkat Stamina Sediaan Sirup Campuran Ekstrak Rimpang Zingiber Officinale Var. Rubrum dan Kaempferia Galanga L. dengan Metode Swimming Test secara In Vivo pada Tikus Putih. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Stamina has an important role in enhancing performance and recovery. This study aims to determine the stamina-enhancing activity of syrup preparation of Zingiber officinale var. Rubrum and Kaempferia galanga L. extracts mixture by using in vivo swimming test method and to determine the effective dose of the extracts mixture which produces the greatest stamina-enhancing activity. Swimming endurance capacity was investigated in 30 male Wistar rats (150-250 g) with health conditions were divided into 5 groups. Treatment groups were orally administered red ginger rhizome and kencur rhizome extracts mixture at various doses (3.50 mg: 7.35 mg; 7.00 mg: 14.70 mg;14.00 mg: 29.40 mg) formulated in syrup, while the negative control group received a placebo syrup and the positive control group received caffeine 1.8 mg/200gram BW of rats. The rats performed a forced swimming test until they were exhausted, then the exhaustive swimming time was recorded. The result showed that the swimming times to exhaustion were longer in the treated groups than in the control groups. The strongest effect was seen in groups treated with red ginger rhizome and kencur rhizome extract mixture (4.00 mg: 29.40 mg). Based on this study, it can be concluded that the administration of red ginger rhizome (Zingiber officinale var. Rubrum) and kencur rhizome (Kaempferia galanga L.) extracts mixture has acted increase the stamina of the male Wistar rats and the most effective as a stamina enhancer that shows the greatest duration of swimming endurance is at a dose 14.00 mg: 29.40 mg

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