SULIS BAYUSENTONO (2023) PERBANDINGAN PEMBENTUKAN TULANG BARU OLEH DEMINERALIZED BONE MATRIX (DBM) DAN TULANG KANSELOUS BEKU KERING (FREEZE DRIED) YANG DITANAM PADA OTOT TIKUS PUTIH. Thesis thesis, Universitas Airlangga.

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Abstract

Background : One alternative for the treatment of extensive bone defects is the use of bone graft. Autogenous bone remains the established standard bone grafting material. However, the availability of bone for harvest is limited. Demineralized bone matrix was ideally used as bone graft substitute because it has osteoinductive and osteoconductive mechanism. On the other hand, freeze dried allograft, which has osteoconductive mechanism, has been widely used in clinic. The purpose of the study was to ascertain that demineralized bone matrix (DBM) is better than Freeze dried allograft in new bone formation through osteoinductive mechanism. Materials and Methods : Eighteen male white rats of 60 days old and weighing about 200-300 gram received standard pellet for rodents and water ad libitum. The rats were divided into three observation groups, each was surgically implanted with a graft in the adductor muscle. Each group consisted six tights implanted with demineralized bone matrix and the other side tight implanted with freeze dried allograft and sacrifieced 2nd weeks, 4th weeks and 6th weeks after implantation (6 rats/period). Histological examination have been performed to asses the number of osteoblast cells and bone matrix formation. The data were tested for normality using Kolmogorov-Smimov test and the result was analyzed with T one-sample test.

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