SEPTIANA, 059912172
(2004)
PENGARUH ASAM 4-HIDROKSISINAMAT DAN ASAM 4-METOKSISINAMAT TERHADAP AKTIVITAS TIROSINASE.
Skripsi thesis, Universitas Airlangga.
Abstract
Tyrosinase is known to be a key enzyme for melanin biosynthesis. Therefore, inhibition in tyrosinase activity will cause a decreasing in melanin production.
The inhibition of cinnamic acid and its derivatives against tyrosinase has been studied as the effort to find a new effective skin-lightening agent. 4hidroxycinnamic acid and 4-metoxicinamic acid as two of cinnamic acid derivatives was tested to know its effect on inhibiting tyrosinase.
To Asses the efficacy of tyrosinase inhibition, tyrosinase activity using LTyrosine as a substrate was assayed spectrofotometrically with the dopachrome method.
Michaelis-Menten constant (Km) and maximum velocity (Vmax) of the enzyme activity were showed by Lineweavar-Burk's plots.
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