Achmad Fuad Hafid, - and NI PUTU ARIANTARI, - and LIDYA TUMEWU, - and AGRIANA ROSMALINA HIDAYATI, - and Aty Widyawaruyanti, - (2012) The Active Marker Compound Identification of Artocarpus champeden Spreng, Stembark Extract, MoraCahlcone A As Antimalarial. The Active Marker Compound Identification of Artocarpus champeden Spreng, Stembark Extract, MoraCahlcone A As Antimalarial, 4. pp. 247-249. ISSN 0975 - 1491

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Abstract

Artocarpus champeden Spreng. (Moraceae), commonly known as ”cempedak”, has been traditionally used for malarial remedies. Several studies reported that A. champeden Spreng. stembark has in vitro and in vivo antimalarial activity. The main aim of this research was to isolate and identify an active marker compound of A. champeden stembark for quality control purpose of A. champeden stembark extract in the development of this extract as phytomedicine antimalarial product. The isolation method was bioactivity guided column chromatography and preparative TLC techniques. The marker compound that has been isolated showed potent antimalarial activity with an IC50 value of 0.18 μg/ml against Plasmodium falciparum 3D7strain. Based on UV, IR, 1H NMR, 2D NMR (COSY, HMBC and HMQC) spectral and identification of other references, the active marker compound was identical with known prenylated chalcone compound, Morachalcone A.

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