Giovanny Azalia Gunawan, NIM011311133280 (2017) EFEK PEMBERIAN EKSTRAK KACANG KENARI (Canarium indicum L.) TERHADAP KADAR KOLESTEROL TOTAL DARAH PADA MENCIT JANTAN (Mus musculus L.) YANG DIBERI DIET TINGGI LEMAK. Skripsi thesis, Universitas Airlangga.

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Abstract

Introduction :Canarium indicum L. has a vitamin, high fiber, omega-3, omega-6 and omega-9 fatty acids which can be used as a drug to treat hyperlipidemia. The main mechanism of occurrence of hyperlipidemia is induced by high-fat diet.The purpose of this study is to find out the hyperlipidemia effect of the Canarium indicum L. usage in reducing the occurence of hyperlipidemia. Methods :This study used pre and post test control group design. Randomly selected of 35 male mices were classified into five groups. Group I (Negative Control, receive high-fat diet and CMC Na 1%), Group II (Positive Control, receive high-fat diet and Statin 125 mg/Kg bodyweight ), Group III (Dosage 1, receive high-fat diet and Canarium indicum L. 125 mg/Kg bodyweight), Group IV (Dosage 2, receive high-fat diet and Canarium indicum L. 250 mg/Kg bodyweight) and Group V (Dosage 3, receive high-fat diet and Canarium indicum L. 500 mg/Kg bodyweight). High-fat diet and Canarium indicum L.was given orally. The parameters measured in this study are the number of total blood cholesterol as a manifestasion of hyperlipidemia. Results :the results of this study showed significant differences betweennegative control group and Group III (p<0,05). Conclusion : Canarium indicum L. with dose 500 mg/kg bodyweight can reduce hyperlipidemia.

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