Muhajirin Dean and Retno Handajani and Junaidi Khotib, NIDN. 0022107001 (2019) Faloak (Sterculia quadrifida R.Br) Stem Bark Extract Inhibits Hepatitis C Virus JFH1. Oriental Journal of Chemistry, 35 (1). pp. 430-435. ISSN 0970-020X

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Abstract

The discovery of antiviral drugs is developing new alternative medication and economics prices. One of the natural resources for alternative medicine is the water extract of faloak stem bark which is a material used by Kupang Community as an antiviral drug. The HCV JFH1 lifecycle inhibition is expressed in IC (inhibitory concentration 50%) and the toxicity of water extract of faloak stem bark in hepatocyte cell line Huh7it is expressed in CC 50 (cytotoxicity concentration 50%). Determining the results obtained using Microsoft Office ®50 Excell 2013. The water extract of faloak stem bark has an inhibition of HCV genotype 2a strain JFH1 with the IC® 11.57 μg/mL and the toxicity water extract of faloak stem bark in the Huh7it cell line hepatocyte with the CC 50 >1000 μg/mL. Mode of action activities from water extract of faloak stem bark can be inhibited all step HCV life cycle. The first step is entry step has the inhibition 93.97%, post-entry step has the inhibition 96.75%, and combination 50 step (entry and post-entry step) has the inhibition was 100%. The active compound in the water extract of faloak stem bark was epicatechin 875 mg/kg. The water extract of faloak stem bark can be a candidate for antivirals against HCV JFH1.

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