Pengaruh Sistem Mikroemulsi Tipe W/O Terhadap Karakteristik Sediaan Dan Pelepasan Natrium Diklofenak (Perbandingan Konsentrasi Surfaktan (Span 80-Tween 80): Kosurfaktan (Etanol 96%) = 6:1 dalam basis gel HPMC 4000)

Nailul Ghayah and Tristiana Erawati and Esti Hendradi (2014) Pengaruh Sistem Mikroemulsi Tipe W/O Terhadap Karakteristik Sediaan Dan Pelepasan Natrium Diklofenak (Perbandingan Konsentrasi Surfaktan (Span 80-Tween 80): Kosurfaktan (Etanol 96%) = 6:1 dalam basis gel HPMC 4000). Jurnal Farmasi Dan Ilmu Kefarmasian Indonesia, 1 (2). pp. 48-54. ISSN 2406-9388

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Official URL: http://journal.unair.ac.id/JFIK@pengaruh-sistem-mi...

Abstract

he aim of this study was to observe the effect of microemulsion system w/o type on the characteristics of dosage form and release of diclofenac sodium in HPMC 4000 gel base. The ratio of surfactant (Span 80-Tween 80): cosurfactant (ethanol 96%), was used to make microemulsion is 6:1. Diclofenac sodium with emulsion in gel base was used as comparator. The evaluation included organoleptic, pH, spread diameter measurement of zero load, and also diclofenac sodium release test from gel base of each formula. Data from pH test, spread diameter measurement of zero load, and flux of drug release test were evaluated based on independent sample t-test. Data analysis showed that pH for microemulsion system in gel base (formula I) was 6.59±0.006 and emulsion system in gel base (formula II) was 6.55±0.047. Spread diameter measurement of zero load for formula I was 7.5±0.10 cm and for formula II was 12.7±0.21 cm. Those data was analyzed using independent sample t-test with degree of confident 95% (α=0.05). The result showed that there was a significant difference between two formulas in spread diameter of zero load but no significant difference in pH. Then, drug release test was carried out with Erweka Dissolution Tester Type DT 820 with apparatus 5 paddle overdisk in phosphate buffer 7.4±0.05, temperature 32°C and paddle rotation speed 100 rpm. The rate of diclofenac sodium release in microemulsion system in gel base was 48.4±0.52 µg/cm 2 /√minute.

Item Type: Article
Uncontrolled Keywords: iclofenac sodium, microemulsion, drug release, HPMC
Subjects: R Medicine
R Medicine > RS Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi
Creators:
CreatorsNIM
Nailul GhayahUNSPECIFIED
Tristiana ErawatiNIDN0018055803
Esti HendradiNIDN0014115703
Depositing User: Mr M. Fuad Sofyan
Date Deposited: 16 Sep 2019 02:14
Last Modified: 02 Jan 2020 05:15
URI: http://repository.unair.ac.id/id/eprint/86376
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