ANDHI SETYAWAN, 050810274 (2012) STUDI PRAFORMULASI PENGARUH SUHU TERHADAP STABILITAS KIMIA Asam p-metoksisinamat. Skripsi thesis, UNIVERSITAS AIRLANGGA.
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Abstract
APMS stability test has been studied by increasing temperature test method. Assay of APMS in citrate buffer solution at pH 6.0 has been done at 50o, 70o and 80o C performed by HPLC method at 286 nm as λmax. Used a mobile phase of methanol: water in the ratio 55: 45. Obtained degradation rates constants (k) 1,382 x 10-3 hour-1 at 50o C, 3,532 x 10-3 hour-1 at 70o C and 4,323 x 10-3 hour-1 at 80o C. Value of (k) at 25o C (k25) by extrapolating the regression equation for the temperature at 4,445 x 10-4 hour-1 and (k25) rates based on the Arrhenius equation by using a comparison of the results obtained k50 4,284 x 10-4 hour-1.
| Item Type: | Thesis (Skripsi) | ||||||
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| Additional Information: | KKB KK-2 FF.F.31/13 Set s | ||||||
| Uncontrolled Keywords: | AMPS, STABILITY TEST, THE CONSTANT DEGRADATION | ||||||
| Subjects: | R Medicine > RM Therapeutics. Pharmacology R Medicine > RM Therapeutics. Pharmacology > RM300-666 Drugs and their actions |
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| Divisions: | 05. Fakultas Farmasi > Farmastika | ||||||
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| Depositing User: | mat sjafi'i | ||||||
| Date Deposited: | 14 Feb 2013 12:00 | ||||||
| Last Modified: | 02 Sep 2016 07:14 | ||||||
| URI: | http://repository.unair.ac.id/id/eprint/9106 | ||||||
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