Erina Widyasari Samudro (2015) Pengaruh Konsentrasi Kitosan Terhadap Pelepasan Asam P-Metoksisinamat Dalam Sistem Nanoemulsi. Skripsi thesis, UNIVERSITAS AIRLANGGA.
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1. HALAMAN JUDUL .pdf Download (327kB) |
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2. ABSTRAK .pdf Download (225kB) |
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3. DAFTAR ISI .pdf Download (255kB) |
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4. BAB I PENDAHULUAN .pdf Download (242kB) |
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5. BAB II TINJAUAN PUSTAKA .pdf Restricted to Registered users only until 23 March 2023. Download (427kB) | Request a copy |
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6. BAB III KERANGKA .pdf Restricted to Registered users only until 23 March 2023. Download (235kB) | Request a copy |
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7. BAB IV METODE PENELITIAN .pdf Restricted to Registered users only until 23 March 2023. Download (402kB) | Request a copy |
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8. BAB V HASIL PENELITIAN .pdf Restricted to Registered users only until 23 March 2023. Download (959kB) | Request a copy |
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9. VAV VI PEMBAHASAN .pdf Restricted to Registered users only until 23 March 2023. Download (257kB) | Request a copy |
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10. BAB VII KESIMPULAN .pdf Restricted to Registered users only until 23 March 2023. Download (223kB) | Request a copy |
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11. DAFTAR PUSTAKA .pdf Download (238kB) |
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12. LAMPIRAN .pdf Restricted to Registered users only until 23 March 2023. Download (950kB) | Request a copy |
Abstract
The aim of this study was to know how much the influence of chitosan as a thickening agent, toward release of p-methoxycinnamic acid in nanoemulsion contained virgin coconut oil. Four formulas were made based on the difference chitosan concentration, i.e FI (0%), FII (0,05%), FIII (0,15%), and FIV (0,3%). Drug release was determined using Franz diffusion cell with cellophane were used as a membrane. The result of this study showed that drug release rate (flux) of p-methoxycinnamic acid from formula I, II, III, and IV were 0,6275±0,02 ; 0,4816± 0,06 ; 0,3634± 0,02 ; dan 0,2913 ± 0,02 (μg/cm2.min). Based on ANOVA one way test, could be concluded the flux of FI>FII>FIII=FIV. There was no significant difference between FIII and FIV. The drug release rate not in accordance with viscosity result. Because of the ionic repulsion on FIV stronger than the inhibition as a result of higher viscosity. The ionic repulsion among the droplets, because of the interaction between cationic polymer of chitosan and surfactant that present on the surface of the droplets, that made the droplets became positively charged.
| Item Type: | Thesis (Skripsi) | |||||||||
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| Additional Information: | KKB KK-2 FF.F.33/15 Sam p | |||||||||
| Uncontrolled Keywords: | p-methoxycinnamic acid, Franz diffusion cell, nanoemulsion, drug release, chitosan. | |||||||||
| Subjects: | Q Science > QD Chemistry > QD1-999 Chemistry | |||||||||
| Divisions: | 05. Fakultas Farmasi > Farmastika | |||||||||
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| Depositing User: | Nn Dhani Karolyn Putri | |||||||||
| Date Deposited: | 19 Feb 2016 12:00 | |||||||||
| Last Modified: | 23 Mar 2020 03:01 | |||||||||
| URI: | http://repository.unair.ac.id/id/eprint/9285 | |||||||||
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