Arlita Wulan Yuniar (2015) Aktivitas Antivirus Influenza A Subtipe H1N1 Pandemi-2009 dan H5N1 Dari Ekstrak Buah Momordica Charantia L. Skripsi thesis, UNIVERSITAS AIRLANGGA.
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Abstract
Objective: To investigate antiviral activity of Momordica charantia L. fruit methanolic extract to inhibit viral growth in embryonated chicken egg infected with influenza A viruses (Subtype pandemic-2009 H1N1 and H5N1). Methods: Momordica charantia L. fruit were extracted using methanol by maceration method. Toxicity test of the methanolic extract was evaluated in embryonated chicken. Antiviral activity was performed in embryonated chicken egg and evaluated by hemaglutination (HA) test. The mean of HA titre will be used to calculate inhibitory percentage of the methanolic extract as an antiviral. Results: This extract did not show any toxic effect (death) in embryonated chicken egg. This extract also showed its effect to reduce viral HA titre, on both influenza A viruses subtype pandemic- 2009 H1N1 and H5N1, compared to the negative control. The percentage of inhibition of this extract against pandemic-2009 H1N1 influenza A virus is 75,5% at concentration 1000 μg/mL. While for H5N1 influenza A virus, the percentage of inhibition is 45,4% at concentration 250 μg/mL. Conclusion: Momordica charantia L. fruit methanolic extract exhibited antiviral activity against influenza A viruses subtype pandemic-2009 H1N1 and H5N1.
| Item Type: | Thesis (Skripsi) | |||||||||
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| Additional Information: | KKB KK-2 FF.FT.36/15 Yun a | |||||||||
| Uncontrolled Keywords: | Momordica charantia L., influenza A, H1N1, H5N1, embryonated chicken egg, hemaglutination test | |||||||||
| Subjects: | Q Science > QD Chemistry > QD415-436 Biochemistry S Agriculture > SF Animal culture > SF600-1100 Veterinary medicine > SF780.2-780.7 Veterinary microbiology, bacteriology, virology, mycology |
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| Divisions: | 05. Fakultas Farmasi > Farmakognosi Fitokimia | |||||||||
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| Depositing User: | Nn Dhani Karolyn Putri | |||||||||
| Date Deposited: | 25 Feb 2016 12:00 | |||||||||
| Last Modified: | 02 Mar 2020 07:33 | |||||||||
| URI: | http://repository.unair.ac.id/id/eprint/9316 | |||||||||
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