Astulla A, - and Hirasawa Y, - and Rahman A, - and Idha Kusumawati, - and Wiwied Ekasari, - and Aty Widyawaruyanti, - and Nor Cholies Zaini, - and Hiroshi Morita, - (2011) Melidianolic acid A and B, new antimalarial acyclic diterpenes from Aphanamixis grandifolia. Natural Product Communications, 6 (3). pp. 323-326. ISSN 1555-9475

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Abstract

Two new acyclic diterpenes, melidianolic acids A (1) and B (2), have been isolated from the bark of Aphanamixis grandifolia. Their structures were elucidated on the basis of spectroscopic and chemical methods. Melidianolic acids A (1) and B (2) showed antimalarial activity against Plasmodium falciparum 3D7 with IC50 of 6.1 and 7.3 microg/mL, respectively.

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