Jennifer Susanto (2020) Pengaruh Ekstrak Wortel (Daucus carota L.) Sebagai Prevensi Ulkus Peptikum Pada Mencit Yang Diinduksi Piroksikam. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Non-Steroidal Anti-Inflammatory Drug (NSAID) contributes a lot to gastrointestinal morbidity due to the complications, one of which is peptic ulcer. Gastric mucosal damage is caused by inhibition of PGE2 and PGI2 secretion, local irritation, neutrophil adhesion, and increased HCl secretion. This experiment proves the effect of carrot (Daucus carota L.) extract as a peptic ulcer prevention on piroxicam induced mice. This is an experimental research using posttest only control group design. Thirty five mice were divided into 5 groups and adapted for 1 week. Negative control group was given 0,25 ml aquadest, positive control group was given 0,104 mg famotidine, group A was given 200 mg/kgBW carrot extract, group B was given 300 mg/kgBW carrot extract, and group C was given 400 mg/kgBW carrot extract. Two hours later, mice were induced by 0,052 mg piroxicam. Treatments were given for 14 days. On the 15th day, mice’ stomachs were taken and fixed. After that, the histopathological prepararations were made. Results of the mucosal thickness using ANOVA method showed p = 0,000 which means there were significant differences between groups (p < 0,05). On the other hand, the results of the histophatological signs of inflammation using Kruskall-Wallis method showed p = 0,000 indicating that there were an effect of the independent variable on its histopathology (p < 0,05). In conclusion, this experiment confirms that carrot (Daucus carota L.) extract is more effective in avoiding peptic ulcer due to NSAID consumption.

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