Romaniyanto, - and Cita Rosita Sigit Prakoeswa, - and Damayanti Tinduh, - and Hari Basuki Notobroto, - and Fedik Abdul Rantam, - and Dwikora Novemberi Utomo, - and Heri Suroto, - and Ferdiansyah Mahyudin, - (2021) The potential of mesenchymal stem‐cell secretome for regeneration of intervertebral disc: A review article. Indonesian Journal of Biotechnology, 26 (2). pp. 61-75. ISSN 1687-708X

	Text (Artikel) C-16_Article_The potential of mesenchymal stem‐cell.pdf Download (1MB)
	Text (Peer Review) C-16_Validasi Kadep dan Peer Reviewer_The potential of mesenchymal stem cell.pdf Download (881kB)
	Text (Similarity) C-16_Turnitin 15_The potential of MSC.pdf Download (3MB)

Abstract

Low back pain is a crucial public health problem that is commonly associated with intervertebral disc de‐ generation and has vast socio‐economic impact worldwide. Current treatments for disc degeneration are conservative, non‐surgical, or surgical interventions, and there is no current clinical therapy aimed at directly reversing the degeneration. Given the limited capacity of intervertebral disc (IVD) cells to self‐repair, treatment aiming to regenerate IVDs is a topic of interest and mesenchymal stem cells (MSCs) have been identified as having potential in this regeneration. Recent studies have revealed that the benefits of MSC therapy could result from the molecules the cells secrete and that play principal roles in regulating essential biologic processes, rather than from the implanted cells themselves. Therefore, the objective of this study is to review the potential use of the MSC secretome to regenerate IVDs. Current evidence shows that the secretome may regenerate IVDs by modulating the gene expressions of nucleus pulposus cells (upregulation of keratin 19 and downregulation of matrix metalloproteinase 12 and matrix Gla protein) and stimulating IVD progenitor cells to repair the degenerated disc.

Actions (login required)

View Item