Isolation of cytotoxic sesquiterpenes from Curcuma comosa and characterization of their structures

Khun Nay Win Tun, .- and Nanik Siti Aminah, .- and Alfinda Novi Kristanti, .- and Rico Ramadhan, .- and Yoshiaki Takaya, .- and Hnin Thanda Aung, .- (2019) Isolation of cytotoxic sesquiterpenes from Curcuma comosa and characterization of their structures. Journal of Indian Chemical Society, 96 (12). pp. 1513-1517. ISSN 00194522

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Abstract

Three quaiane-type sesquiterpenes named curcumenol (1), zedoarondiol (2), and (1S,4S,5S,10R)-isozedoarondiol (3) were isolated from the rhizomes of Curcuma comosa. Their structures were elucidated on the basis of extensive spectroscopic analysis. The cytotoxic activities of all isolated compounds were tested by MTT assay. Compounds 2 and 3 showed the most potent activities against T47D cell line with IC50 values 12.13 and 10.93 g/mL, respectively.

Item Type: Article
Uncontrolled Keywords: Curcuma comosa, Zingiberaceae, quaiane-type sesquiterpenes, MTT assay.
Subjects: Q Science
Q Science > QD Chemistry
Divisions: 08. Fakultas Sains dan Teknologi > Kimia
Creators:
CreatorsNIM
Khun Nay Win Tun, .-UNSPECIFIED
Nanik Siti Aminah, .-UNSPECIFIED
Alfinda Novi Kristanti, .-UNSPECIFIED
Rico Ramadhan, .-UNSPECIFIED
Yoshiaki Takaya, .-UNSPECIFIED
Hnin Thanda Aung, .-UNSPECIFIED
Depositing User: Mr Vega Andi Budiman
Date Deposited: 17 Mar 2022 05:53
Last Modified: 17 Mar 2022 05:53
URI: http://repository.unair.ac.id/id/eprint/113735
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