Yosuke Matsuno, - and Jun Deguchi, - and Yusuke Hirasawa, - and Kunio Ohyama, - and Hiroo Toyoda, - and Chieko Hirobe, - and Wiwied Ekasari, - and Aty Widyawaruyanti, - and Noor Cholies Zaini, - and Hiroshi Morita, - (2008) Sucutiniranes A and B, new cassane-type diterpenes from Bowdichia nitida. Bioorganic and Medicinal Chemistry Letters, 18 (13). pp. 3774-3777. ISSN 0960-894X

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Abstract

Two new cassane-type diterpenes, sucutiniranes A (1) and B (2), have been isolated from the seeds of Bowdichia nitida together with 6α-acetoxyvouacapane (3) and 6α,7β-diacetoxyvouacapane (4), and the structures of 1 and 2 were elucidated by using 2D NMR data and chemical correlations. Sucutinirane A (1) and 3 showed a moderate cytotoxicity against human colon carcinoma COLO201 cells, and 6α,7β-diacetoxyvouacapane (4) showed in vitro antiplasmodial activity against parasite Plasmodium falciparum 3D7.

Item Type:	Article
Uncontrolled Keywords:	Diterpene, Sucutinirane A, Sucutinirane B, Bowdichia nitida, Cytotoxicity, Antiplasmodial activity
Subjects:	R Medicine R Medicine > RS Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS200-201 Pharmaceutical dosage forms
Divisions:	05. Fakultas Farmasi > Farmakognosi Fitokimia
Creators:	Creators NIM Yosuke Matsuno, - - Jun Deguchi, - - Yusuke Hirasawa, - - Kunio Ohyama, - - Hiroo Toyoda, - - Chieko Hirobe, - - Wiwied Ekasari, - NIDN0022016902 Aty Widyawaruyanti, - NIDN0026046210 Noor Cholies Zaini, - - Hiroshi Morita, - -
Depositing User:	Mr M. Fuad Sofyan
Date Deposited:	30 May 2022 00:29
Last Modified:	02 Aug 2022 08:16
URI:	http://repository.unair.ac.id/id/eprint/116537
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