Noi Maya Anggrita Sari, Noi and Iswinarno Doso Saputro, Iswinarno and Magda Rosalina Hutagalung, Magda Vascular Endothelial Growth Factor, Epidermal Growth Factor, and Epithelialization Analysis on Full-Thickness Wound Applied with Topical Erythropoietin. Open Access Macedonian Journal of Medical Sciences, 10 (B). ISSN 18579655

	Text (Artikel) 22.pdf Download (1MB)
	Text (Turnitin) Turnitin_compressed (1).pdf Download (455kB)
	Text (Bukti Korespondensi) Korespondensi (22. VascularEndhothelial Growth Factor, Epidermal...).pdf Download (20kB)
	Text (Kualitas Karil & Kesesuaian Bidang Ilmu) 22. Validasi (Vascular Endhotelial...).pdf Download (498kB)

Abstract

stractBACKGROUND: Skin wounds are a major challenge, such as full-thickness wounds that need a long time to heal. However, the addition of erythropoietin can accelerate the wound healing process.AIM: This study was aimed to determine the effect of topical erythropoietin administration on vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), and epithelialization in the wound healing process.METHODS: This was randomized controlled trial. Full-thickness wounds were created on the back of each white rat. No treatment was administered in the control group (n=16), and topical erythropoietin was applied in the treatment group (n=16). The rats were euthanized on day 3 and day 6 post-surgery, respectively. The expression levels of VEGF, EGF, and microscopic epithelialization rate were examined.RESULTS: The level of EGF expression in the treatment group increased significantly on day 3 by 2.84 times compared to the control group and on day 6 increased to 4.89 times compared to the control group (p < 0.001). The level of VEGF expression in the treatment group on day 3 increased 2.18 times compared to the control group and on day 6 increased to 2.65 times compared to the control group (p < 0.001). Meanwhile, epithelialization in the treatment group on day 3 increased 1.3 times compared to the control group and on day 6 increased up to 7.62 times compared to the control group (p < 0.001).CONLUSION: Topical administration of erythropoietin could increase the expression of VEGF, EGF, and epithelialization in both early inflammatory and proliferative phases

Actions (login required)

View Item