Dedy Setiawan, - and Alpha Fardah Athiyah, - and I Gusti Made Reza Gunadi Ranuh, - and Andy Darma, - and Subijanto Marto Sudarmo, - (2022) Effect of Probiotic on Repair of Ethanol-induced Gastric Mucosal Erosion in Wistar Rats. International Journal of Scientific Advances, 3 (3). pp. 363-367. ISSN 2708-7972

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Abstract

Background: Probiotics can increase mucus secretion as a mechanism to improve barrier function and pathogen exclusion. Several Lactobacillus species can increase mucin expression in human intestinal cells. Lactobacillus Plantarum IS-10506 is a probiotic native to Indonesia derived from curd, fermented milk from Sumatra. Research with Lactobacillus Plantarum IS-10506 showed a protective effect as well as a therapeutic effect on intestinal mucosal damage to the ileum. Objective: Analyzing the effect of probiotic Lactobacillus Plantarum IS-10506 on the acceleration of ethanol-induced gastric mucosal erosion regeneration. Method: Experimental research used 48 rats that were fasted and divided into 3 groups those are K1 group control group, group K2 which was treated with ethanol 43%, and group K3 which was treated with ethanol and probiotic Lactobacillus Plantarum IS-10506. Each group was divided into 4 subgroups based on the day of the sacrifice those are days 1, 3, 5, and 7. The treatment of the test animals is done in 7 days. Epithelial defect was measured by using histopathologic scoring by Roger’s Results: The score of Epithelial defect Group K2 was significantly different compared to group K1 (p=0.036), and K3 (p=0.007). The gastric mucosal repair was completed in day 7 in the probiotic group. Conclusion: Probiotic Lactobacillus Plantarum IS-10506 accelerate mucosal repair in etanol induced gastric mucosal injury.

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