Havid Yusuf (2013) Pengaruh Latihan Eksentrik Terhadap Ekspresi GLUT-1 Pada Otot Gastrocnemius Mencit Diabetes Mellitus Yang Diinduksi Streptozotocin. Thesis thesis, UNIVERSITAS AIRLANGGA.
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Abstract
Diabetes Mellitus is a disease with characterized by an inc1 easing glucose level in the blood (hyperglycemia). Physical exercise for people who sutTer from OM has an important role in controlling blood glucose level in blood. Eccentric muscle contraction can stimulate translocation and the expression of G LUT-1 to cell membrane, which has as role to facilitate the glucose entrance into the cell. However, the influence of eccentric exercise to increase GLUT-I expression on cell membrane has not been clearly known. The purpose of this research is to prove that eccentric exercise can increase the amount of GLUT-I expression in the gastrocnemius muscle of diabetic mice. The research method used is the randomize posttest only kontrol group design The trial animal used in this research are 8-I2 weeks-male mice, body weight between 25±2 grams. The total amount of 27 trials animals were divided randomly in to 3 groups, normal-control group (KO), diabetic-control group (K I), and diabetic-group with treatment (K2). K 1 and K2 were inducted with streptozotocin. KO and KI undergone no treatment. K2 underwent eccentric exercise treatment. The exercise was done using a treadmill with as slope angle of -I 0 degrees (running downhill). The time period of exercise was I6 minutes 30 seconds with as speed of 21 em/second. Fasting blood glucose (GOP), post prandial blood glucose (GDPP), and GLUT-I were taken from each trial group. The mean GLUTI 's of K2 (3.04/J.tm2 , SD=0.68) is higher than that of KI (1.88/J.tm2 , SD=0.20) (p=O.OOI ). Analysis shows a significant difference between GLUT-I of KI and K2 (p=O.OOl). This is an evidence the amount of GLUT -1 expression on cell membrane of eccentric exercise are much higher than that without eccentric exercise. In conclusion, eccentric exercise increases glucose uptake in muscles, hence it improves the blood glucose level.
| Item Type: | Thesis (Thesis) | |||||||||
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| Additional Information: | - | |||||||||
| Uncontrolled Keywords: | diabetes mellitus, eccentric exercise, GLUT-1. | |||||||||
| Subjects: | R Medicine > RC Internal medicine > RC1200 Sports Medicine R Medicine > RC Internal medicine > RC31-1245 Internal medicine |
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| Divisions: | 01. Fakultas Kedokteran > Magister Ilmu Kesehatan Olahraga | |||||||||
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| Depositing User: | Novita | |||||||||
| Date Deposited: | 31 Mar 2023 04:17 | |||||||||
| Last Modified: | 31 Mar 2023 04:17 | |||||||||
| URI: | http://repository.unair.ac.id/id/eprint/121463 | |||||||||
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