Ira Arundina, - and Theresia Indah Budhy S., - and Wisnu Setyari Juliastuti, - and Meircurius Dwi Condro Surboyo, - and Anisa Nur Halimah, - and Putrisa Lestari, - (2022) The expression of interleukin‑1β and nuclear factor erythroid‑2 in the periodontitis after treatment of liquid smoke rice hull. Journal of Advanced Pharmaceutical, 13 (2). pp. 95-99. ISSN 01105558

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Abstract

Nonsurgical treatment such as scaling and root planing has been the main therapy of periodontal management. However, some individuals are nonresponsive with only mechanical therapy. Rice hull liquid smoke (RH‑LS) with higher of phenolic compound supposed to interfere with inflammation process. Thus, the purpose of this study is to investigate the anti‑inflammation properties of RH‑LS for chronic periodontitis adjunct therapy by observing the expression of nuclear factor erythroid‑2 (Nrf‑2) and interleukin‑1β (IL‑1β). Two groups of Wistar rats were used. Control group was induced by 1 × 109 colony‑forming unit (CFU)/ml Porphyromonas gingivalis (PG) and treated with aquadest for 2 and 7 days. Meanwhile, the other group was induced by 1 × 109 CFU/ml PG and treated with RH‑LS for 2 and 7 days. Two central incisive/mandibulae were dissected and stained with immunohistochemistry for analyzed the expression of Nrf‑2 and IL‑1β. Data were then analyzed statistically using independent t‑test (P = 0.05). Treatment with RH‑LS for 7 days showed lower expression of IL‑1β (4.00 ± 1.58) than control group (13.60 ± 2.70) and showed higher expression of Nrf‑2 (11.60 ± 1.95) than control group (4.20 ± 1.64) (P = 0.000) (P < 0.05). Treatment of RH‑LS for 2 days showed higher expression of Nrf‑2 (2.20 ± 1.31) than control group (6.80 ± 1.92) (P = 0.003) (P < 0.05). RH‑LS showed anti‑inflammation properties by elevating the expression of Nrf‑2 and depressing expression of IL‑1β in periodontitis induced by PG.

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